Searchable abstracts of presentations at key conferences in endocrinology

ea0056gp220 | Reproduction | ECE2018

Depletion of the primate-specific luteinizing-hormone receptor splice variant ‘exon-6A’ impairs LH-, but not hCG-mediated signaling in human primary granulosa cells

Casarini Livio , Riccetti Laura , Sperduti Samantha , Lazzaretti Clara , Masini Alessia , Simoni Manuela

Introduction: A primate-specific luteinizing hormone (LH) receptor (LHCGR)-variant was suspected to discriminate between maternal choriogonadotropin (hCG)- and fetal LH-functioning. It is the so-called “LHCGRex6A”, truncated, intracellular receptor isoform produced by alternative cryptic exon stop-codons located between the 6th-7th out of 11 exons. Its function is unknown, although pseudohermaphroditism and 46-XY female-like phenotype were associated with LHCGRex...