Endocrine Abstracts

Background: Turner syndrome is a lifelong condition that requires lifelong engagement with health services. The Paediatric Endocrinologist has a role in developing a plan for transition and establishing follow-up in an adult clinic. A clinic proforma outlining expected investigations during transition has been in use in the Glasgow Turner clinic since 2015 based on the recommendations of the Turner Syndrome Study Group. More recently The Endocrine Society Transition Toolkit ha...

Introduction: A Patient Held Record (PHR) has been developed for use in adolescent girls with Turner Syndrome (TS) attending a dedicated Turner Transition clinic, RHC Glasgow. The PHR has been devised to encourage knowledge of TS; medcial care and ways to maintain good health and to promote self advocacy.Aim: To assess patient acceptability and user friendliness of a PHR in adolescent girls with TS.Method: A PHR and questionnaire w...

Background: A Turner Syndrome (TS) Transition clinic, Royal Hospital for Children Glasgow(RHCG), with paediatric and adult endocrinology/gynaecology teams was set up in 1998.Objective: 1) To evaluate the success of TS transition2) To determine what factors influence long-term follow-up in an adult service – good early attendance in an adult clinic and meeting an adult specialist prior to transfer to adult clinic.<p class="...

The British Society for Paediatric Endocrine and Diabetes (BSPED) published guidance in 2016 on optimal Hormonal Replacement Therapy (HRT) for pubertal induction in Turner Syndrome (TS). Transdermal preparations of oestrogen are the most appropriate method of oestrogen delivery in TS, as it avoids first pass metabolism of the liver, and thereby does not exert a meaningful effect on blood pressure.Objective: To assess change in prescribing practice in acc...

Background: Turner Syndrome (TS) is a complete or partial loss of the second X chromosome affecting approximately 1:2000 females, classically associated with short stature and hypogonadism. Cardiovascular complications in TS include increased risk of congenital cardiac malformations, hypertension, ischaemic heart disease and aortic dissection. Cardiovascular related deaths account for over 40% of the excess mortality in TS and requires lifelong monitoring and follow-up. The Cl...

In 2019, we attended a patient engagement zoom session, hosted by Turner Syndrome Support Society (TSSS), to launch a video illustrating the use of a transdermal patch for pubertal induction in girls with Turner Syndrome (TS). Several girls raised to us that they felt that they did not have a good understanding of puberty, and on why it was important to receive both oestrogen and progesterone preparations during pubertal induction. To target this, we developed an explanatory v...

Introduction: Turner syndrome (TS) is a chromosomal disorder characterised by an abnormality of or a partial or complete absence of one of the X chromosomes in a phenotypic female. The TS population experience aortic dissection at a rate ten times that of the general population, for which hypertension is a modifiable risk factor. Our primary aim was to determine the frequency of hypertension in girls attending a tertiary paediatric dedicated TS clinic in the West of Scotland a...

Background: Cardiovascular related deaths account for over 40% of the excess mortality in Turner Syndrome (TS). Hypertension, a modifiable risk factor for both aortic dilatation and dissection, is more commonly encountered in TS during childhood and adolescence. The objective of this systematic review and meta-analysis is to determine the prevalence of hypertension in paediatric patients with TS and in relation to the methodologies of blood pressure evaluation.<p class="ab...

Background: Transition is an important stage in the care of a young person with a long-term endocrine condition.Objective: To explore current services for young people (YP) with endocrine conditions from the perspective of paediatric and adult endocrinologists, and YP and their parents using their services.Methods: There were two components:- i). service questionnaire for completion by paediatric and adult endocrinologists ii). &#1...

Background: Girls with Turner Syndrome (TS) are at increased risk of primary ovarian failure. Previous studies have demonstrated that urinary gonadotrophins (UG) can be used as a non- invasive biochemical marker of pubertal status but their value in monitoring and managing girls with primary ovarian failure is unclear.Aims: To determine the range of UG in girls with Turner Syndrome (TS) and its correlation to serum LH and FSH.Patie...