Searchable abstracts of presentations at key conferences in endocrinology

ea0063ep123 | Reproductive Endocrinology | ECE2019

Klinefelter syndrome and hypogonadotropic hypogonadism: an unusual presentation

Matos Tania , Costa Cristiana , do Vale Sonia

Introduction: Klinefelter syndrome (KS) is the most common genetic form of male hypogonadism, despite becoming evident only after puberty. The syndrome is characterized by a primary gonadal defect, which results in small testes due to hyalinization of the seminiferous tubules, low to low normal range of serum testosterone levels and elevated serum gonadotrophins. Paradoxically, a few cases have been described, presenting with hypogonadotropism.Case-repor...

ea0081p325 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Association between the coefficient of glycemic variation and time in range, below and above range in continuous monitoring glucose systems in type 1 diabetes

Gomes da Costa Cristiana , Matos Tania , Vale Sonia

Introduction: Glycemic variability (GV) is a major consideration when evaluating quality of glycemic control. Coefficient of glycemic variation (%CV) is the metric of choice to define GV. International consensus on continuous glucose monitoring (CGM) recommends a %CV <36. Additional studies suggest that low %CV minimize hypoglycemia events <54 mg/dl.Aims: The aim of this analysis is to examine the expected relationship between the coefficient of ...

ea0063p864 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

X-linked adrenoleukodystrophy phenotype evolution - is family history important?

Matos Tania , Jorge Zulmira , Costa Cristiana , do Vale Sonia

X-linked adrenoleukodystrophy (X-ALD) is an inherited disorder of peroxisomal metabolism, characterized by deficient beta-oxidation of saturated very long chain fatty acids (VLCFA). The accumulation of VLCFAs is associated with demyelination of the nervous system, and impairment of steroid hormone synthesis in the adrenal cortex and the testis. The range of phenotypic expression is wide and dynamic. The three presentations most commonly seen are the childhood cerebral forms, a...

ea0063ep12 | Adrenal and Neuroendocrine Tumours | ECE2019

Lost to follow-up in classic congenital adrenal hyperplasia: a case report

da Costa Cristiana Gomes , Matos Tania , do Vale Sonia

Introduction: Classic congenital adrenal hyperplasias (CAH) are mostly diagnosed in the first months/years of life and require a lifetime follow-up.Case report: A 33-year-old Caucasian man was admitted twice in the previous year to the emergency department; the first episode due to an acute tonsillitis, the second episode due to a lower respiratory tract infection, both associated with hyponatremia (125 mmol/l). Common causes of hyponatremia were exclude...

ea0056ep27 | Adrenal and Neuroendocrine Tumours | ECE2018

Optic neuritis and ectopic Cushing Syndrome: a case report

Matos Tania , Costa Cristiana , Martins Ana Filipa , Vale Sonia

Introduction: Ectopic Cushing syndrome caused by a neuroendocrine tumor is uncommon and it’s diagnosis is often delayed. Optic neuritis is another rare disease, with some cases also associated to neuroendocrine tumors.Case-report: A 43-year-old female was referred to the endocrinology outpatient’s department due to obesity. She had a past history of bilateral optic neuritis of unknown etiology. She complained of weight gain, hair loss, acne, hi...

ea0056p66 | Adrenal cortex (to include Cushing's) | ECE2018

Evaluation of cardiometabolic profile of patients submitted to unilateral adrenalectomy

Castro Raquel Vaz de , Costa Cristiana , Matos Tania , Quadros Catarina , Lopez Dolores , Vale Sonia do , Bugalho Maria Joao

Background and aims: It is known that unilateral adrenalectomy as treatment for autonomous secreting adrenal cortex adenomas effectively reduces cardiometabolic risk. Non-autonomous secreting adenomas are not expected to increase cardiometabolic risk, but this has not been thoroughly explored.We evaluated the blood pressure and glycemic profile before and after unilateral adrenalectomy for both autonomous and non-autonomous secreting adrenal cortex adenomas.<p class="abste...

ea0056p517 | Diabetes therapy | ECE2018

Long-term results of continuous subcutaneous insulin infusion on glycemic control and severe hypoglycemias

do Vale Sonia , Carvalho Raquel , Matos Tania , Costa Cristiana , Filipa Martins Ana , Silvestre Catarina , Joao Bugalho Maria

Introduction: The use of Continuous Subcutaneous Insulin Infusion (CSII) is expected to improve glycemic control and to reduce hypoglycemia events. However, long-term beneficial results in glucose control are not always observed. We evaluated long-time glucose control and severe hypoglycemias in type 1 diabetic patients using CSII, without continuous glucose monitoring.Patients and methods: This was a retrospective study of adult type 1 diabetic patients...