Searchable abstracts of presentations at key conferences in endocrinology

ea0015p345 | Thyroid | SFEBES2008

Fixed and calculated doses of radioiodine achieve similar cure rate for hyperthyroidism

George Jyothis , Matthews David , McIntyre Elizabeth

Background: Radioiodine ablation is an effective curative treatment for hyperthyroidism in virtually all patients with single or multiple doses. The dosage of radioiodine used in the treatment of thyrotoxicosis has varied widely according to local experience and practice. Administration of low doses could lead to inadequate or delayed response, while using larger doses is associated with the risk of increased incidence of hypothyroidism.Introduction: In ...

ea0027oc4.3 | Oral Communications 4 | BSPED2011

Non-linear dynamic analysis of glucose regulation in subjects with type 2 diabetes and controls: observed variability and lability (OVAL)

Hill Nathan , Hindmarsh Peter , Tsapas Apostolos , Matthews David

Introduction: Glucose homeostasis is central to the understanding of diabetes and is influenced by hormones and by substrate flux. This implies a non-linear system which has been confirmed by time series analysis. A dynamic systems approach is required for describing the inter-relationship of glucose and insulin and we describe a method that measures a mathematical domain of glucose homeostasis termed the observed variability and lability (OVAL).Methods:...

ea0027p61 | (1) | BSPED2011

Young people have a limited knowledge about diabetes research

Chester Paul , Greene Alex , Lowes Lesley , Kennedy Eleanor , Matthews David

Individuals considering research participation are provided with information but this is usually at the end of the process of engagement. Getting young people interested in research can be difficult, even more so when competing against a demanding school and social life that many young people lead. Working with a group of young people we produced a pilot website containing video and text material about diabetes and research that was designed to be appealing and informative.</p...

ea0027oc1.5 | Oral Communications 1 | BSPED2011

Deconvolution analysis of 24 h serum cortisol profiles informs the amount and distribution of hydrocortsione replacement therapy

Hindmarsh Peter , Hill Nathan , Dattani Mehul , Peters Catherine , Charmandari Evangelia , Matthews David

Introduction: Glucocorticoid replacement therapy uses twice or thrice daily regimens of hydrocortisone (HC) with variable distribution of the dose over the day. Deconvolution analysis determines the mass of hormone that needs to be secreted to attain a particular serum concentration. We have used this methodology to determine the amount and distribution of cortisol over a 24 h period.Methods: Seventy-nine adults (41M) aged 60–74 years and 30 childre...