Endocrine Abstracts

Introduction: We present cases of metastatic pheochromocytoma highlighting diagnostic, management, and therapeutic challenges. Case-1: 69 Female, presented with breathlessness, palpitations, and sweating of 4 months. Panic attacks of 10 years. Imaging confirmed left-sided pheochromocytoma, bone, liver, and pulmonary metastases. Plasma metadrenaline (MT) 4471 pmol/l (0-510), normetadrenaline (NMT) >25000 pmol/l (0-1180) LVEF 30%, global LV hypokinesia...

Primary hyperparathyroidism (PHP), usually due to multigland hyperplasia, occurs in >90% of patients with multiple endocrine neoplasia type 1 (MEN1). The literature is divided on the optimal surgical management for such patients. We report a retrospective cohort study on the long-term outcomes associated with limited, subtotal, or total parathyroidectomy as initial surgery for PHP in MEN1. The primary endpoint was recurrent PHP defined as an adjusted serum calcium >2.6 mmol/l ...

We report a retrospective, single centre observational study to determine the characteristics and outcomes of pancreatic insulinoma. Interrogation of the Oxford NET database, a departmental database of new NET MDT referrals since 2011 (n = 1059), revealed 23/1059 (2.1%) patients with insulinoma diagnosed and treated between 2011 and 2018. Patient records were reviewed and data was captured on demographics, presentation, investigations, treatments and outcomes: 15/23 (...