Searchable abstracts of presentations at key conferences in endocrinology

ea0021p363 | Steroids | SFEBES2009

Is increased 11β-HSD1 expression a key factor underpinning intrinsic and extrinsic skin aging?

Tiganescu Ana , Mayes Andrew , Hardy Rowan , Stewart Paul , Walker Elizabeth

Glucocorticoids are highly detrimental to skin integrity and function both when used locally for anti-inflammatory treatments and during conditions of raised systemic concentrations such as Cushing’s syndrome. Many of the adverse effects of glucocorticoids on skin are also symptoms associated with natural intrinsic aging and extrinsic photoaging.Locally, glucocorticoid availability is regulated independently of circulating levels by 11β-hydroxy...