Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep285 | Calcium and Vitamin D metabolism | ECE2015

Low extracellular sodium promotes adipogenic commitment of human mesenchymal stromal cells: a novel mechanism for chronic hyponatremia-induced bone loss

Deledda Cristiana , Fibbi Benedetta , Giuliani Corinna , Benvenuti Susanna , Luciani Paola , Mazzanti Benedetta , Saccardi Riccardo , Peri Alessandro

Hyponatraemia represents an independent risk factor for osteoporosis and fractures, affecting both bone density and quality. A direct stimulation of osteoclastogenesis and bone resorption in the presence of reduced extracellular sodium concentrations ([Na+]) has been shown, but, to date, the effects of reduced [Na+] on osteoblasts have not been elucidated. This study investigated the effects of a chronic reduction of extracellular [Na+], independently of osmotic stress, on hum...

ea0041gp136 | Obesity | ECE2016

A novel human fetal brown stem cell functional model to study brown adipogenesis

Franco Alessandra Di , Guasti Daniele , Squecco Roberta , Mazzanti Benedetta , Rossi Francesca , Idrizaj Eglantina , Gallego-Escuredo Jose , Villarroya Francesc , Bani Daniele , Forti Gianni , Vannelli Gabriella Barbara , Luconi Michaela

The potential therapeutic applications of targeting brown adipose tissue open new clinical avenues in fighting against metabolic pathologies. However, due to the limited brown depots in adult humans, dramatically reduced after birth, solid cell models to study human brown adipogenesis and its pathophysiological regulation are urgently needed.In our study, we characterized a novel human model of brown adipose stem cells, hfB-ASC, derived from fetal inters...

ea0035oc11.4 | Diabetes and Obesity 2 | ECE2014

A novel adult human adipose stem cell model from inducible brown fat surrounding pheochromocytoma tumors

Di Franco Alessandra , Guasti Daniele , Mazzanti Benedetta , Ercolino Tonino , Nesi Gabriella , Bani Daniele , Forti Gianni , Mannelli Massimo , Valeri Andrea , Luconi Michaela

The recent discovery of the presence of brown adipose tissue (BAT) also in human adults is pivotal for development of anti-obesity therapies. This type of fat, in fact, mainly consists of brite cells (brown adipocytes appearing for a browning process in white fat) which are involved in adiposity control. The origin of brite cells in adult white adipose tissue (WAT) is still unclear as human cell models are lacking.Our study demonstrated the presence of B...