Searchable abstracts of presentations at key conferences in endocrinology

ea0020p630 | Reproduction | ECE2009

Free thiols in human spermatozoa: correlation with Na+/K+-ATPase, Ca2+-ATPase activities and sperm motility

Vignini Arianna , Buldreghini Eddi , Nanetti Laura , Raffaelli Francesca , Paggi Francesca , Boscaro Marco , Mazzanti Laura , Balercia Giancarlo

The aim of the present study was to measure free thiols content, Na+/K+-ATPase, Ca2+-ATPase activities in human spermatozoa of asthenozoospermic patients and normospermic donors, and evaluate any influence on kinetic sperm features, as well as correlation with peroxynitrite. In fact, membrane integrity and its composition are the basic characteristics of the sperm membrane, thus, it is evident that its composition is an important factor for mem...

ea0070aep782 | Reproductive and Developmental Endocrinology | ECE2020

New data in turner syndrome: Results from a long-term prospective observational study from diagnosis to adulthood

Corzani Francesca , Cecchetti Carolina , Oriolo Claudia , Altieri Paola , Perri Annamaria , Scarano Emanuela , Mazzanti Laura , Pagotto Uberto , Gambineri Alessandra

Turner syndrome (TS), one of the most frequent chromosomal aberrations in females, is characterized not only by structural abnormalities (somatic and congenital) but also by acquired comorbidities, such as metabolic disorders, cardiovascular alterations, autoimmune diseases, osteoporosis, and malignancies. The prevalence of structural abnormalities that usually complicate TS at diagnosis is well known. However, the prevalence of acquired complications, that may appear at any a...

ea0016p650 | Reproduction | ECE2008

Reactive nitrogen species in the chemical biology of sperm functions

Vignini Arianna , Bildreghini Eddi , Nanetti Laura , Raffaelli Francesca , Paggi Francesca , Mazzanti Laura , Mantero Franco , Boscaro Marco , Balercia Giancarlo

Inflammation activates a variety of inflammatory cells, which induce and activate several oxidant-generating enzymes which are able to produce high concentrations of free radicals and oxidants which react with each other to generate other more potent reactive oxygen and nitrogen species such as peroxynitrite (ONOO−) that can damage DNA, RNA, lipids, and proteins by nitration, oxidation, etc., leading to increased mutations and altered functions of enzymes and ...