Searchable abstracts of presentations at key conferences in endocrinology

ea0029oc8.4 | Bone | ICEECE2012

Radiological vertebral fractures in hospitalized elderly patients with heart failure

Mazziotti G. , Baracca M. , Doga M. , Porcelli T. , Vescovi P. , Giustina A.

Heart failure (HF) has been associated with bone loss and an increased risk of fragility fractures. Indeed, most of literature data on fractures were based on an historical and clinical approach focused on the identification of peripheral fractures, whereas the risk of vertebral fractures in this clinical setting is still unclear. In this study, we aimed at evaluating the prevalence of radiological vertebral fractures in 791 consecutive elderly and hospitalized patients (372 f...

ea0029p1463 | Pituitary Clinical | ICEECE2012

META-analysis on the effects of octreotide on tumor mass in acromegaly

Mazziotti G , Torri V , Spinello M , Floriani I , Melmed S , Giustina A

The long-acting somatostatin analogue octreotide is used either as an adjuvant or primary therapy to lower GH levels in patients with acromegaly and may also induce pituitary tumor shrinkage. However, inconclusive evidences in this respect have been produced by either single-center research paper or pooled analyses. Therefore, we performed a meta-analysis to thoroughly assess the current literature on the effect of octreotide on pituitary tumor shrinkage. A computerized Medlin...

ea0026p243 | Pituitary | ECE2011

Diabetes mellitus as adjunctive risk factor for vertebral fractures in men with acromegaly

Mazziotti G , Bianchi A , Gola M , Porcelli T , De Marinis L , Giustina A

GH excess is considered as one of the causes of secondary osteoporosis with an increased risk of vertebral fractures in men and post-menopausal women with acromegaly. GH excess in acromegaly is also frequently associated with type 2 diabetes which is considered as a risk factor for fragility fractures in the general population. In this cross-sectional study, we evaluated whether type 2 diabetes may influence the prevalence vertebral fractures in acromegaly. Fifty-seven males w...

ea0026p244 | Pituitary | ECE2011

Hyperprolactinemia is a risk factor for radiological vertebral fractures in post-menopausal women

Mazziotti G , Mancini T , Mormando M , De Menis E , Bianchi A , Doga M , De Marinis L , Giustina A

Hyperprolactinemia may cause bone loss in pre-menopausal women and men. Data on fractures are scanty and it is still unclear which is the skeletal impact of hyperprolactinemia in post-menopausal women. The aim of this study was to evaluate the prevalence of vertebral fractures in post-menopausal women with hyperprolactinemia.Forty post-menopausal women (median age 57 years, range: 47–81) with prolactin (PRL)-secreting adenoma and 119 control post-me...

ea0004p96 | Thyroid | SFE2002

Do Changes In Serum Leptin Influence The Outcome Of Postpartum Thyroid Dysfunction?

Mazziotti G , Casanueva F , Lage M , Premawardhana L , Parkes A , Lazarus J

Experimental evidence suggests that leptin plays an important role in modulation of cell-mediated immunity in organ-specific autoimmune diseases. This longitudinal study evaluates changes in serum leptin values in relation to development and outcome of postpartum thyroiditis (PPT). Materials and Methods: Fifty postpartum (6 week) euthyroid women with elevated thyroglobulin (TgAb) and/or thyro-peroxidase (TPOAb) antibodies were investigated. Body mass index (BMI), serum leptin ...