ea0104p191 | Reproductive Endocrinology | SFEIES24
Mc Guigan Orla
, Sridhar Ananyaa
, Khan Dawood
, Flatt Peter R.
, Moffett Charlotte R.
Background/aims: Obesity is a major risk factor for endometrial cancer with estrogens in combined oral contraceptives enhancing the severity of the disease. This study aims to explore the effect of synthetic estrogen ethinylestradiol (EE2) commonly used in oral contraceptives, on endometrial morphology and regulatory markers in diet-induced obese mice.Methods: Female TO mice were on a high-fat diet (HFD) for 27 weeks. Three groups (n = 5) were g...