Searchable abstracts of presentations at key conferences in endocrinology

ea0038p402 | Steroids | SFEBES2015

Bioinformatic analysis of microRNAs associated with aldosterone secretion

Ab Razak Nur Izah , MacKenzie Scott M , Diver Louise A , McBride Martin M , Davies Eleanor

Many cases of hypertension are associated with inappropriately high levels of aldosterone secretion and it has been proposed that microRNAs play a role in this dysregulation. Previously, we showed that microRNAs expressed within the adrenal cortex significantly repress aldosterone production. Furthermore, stimulation of aldosterone secretion by three different means in the H295R cell line – the most commonly-used in vitro model of the human adrenal cortex – ...