Searchable abstracts of presentations at key conferences in endocrinology

ea0011p488 | Endocrine tumours and neoplasia | ECE2006

Multiple Endocrine Neoplasia Type 1 (MEN 1) is associated with insulin resistance and an increased prevalence of diabetes and impaired fasting glucose

McCallum RW , Parameswaran V , Burgess JR

MEN 1 is an autosomal dominant syndrome associated with benign and malignant neuroendocrine neoplasia. It is characterised by primary hyperparathyroidism, pituitary neoplasia and foregut lineage neuroendocrine tumours. It has also been associated with premature cardiovascular death. Since diabetes is associated with an increased risk of cardiovascular mortality we investigated the prevalence of diabetes (DM) and impaired fasting glucose (IFG) in a large cohort of patients with...

ea0011p78 | Clinical case reports | ECE2006

Synchronous malignant para-aortic phaeochromocytoma and vagal nerve paraganglioma in a patient with germline SDHB mutation

McCallum RW , Stanton P , Walker S , Parameswaran V , Greenaway T

Phaeochromocytomas and paragangliomas arising as part of familial syndromes such as multiple endocrine neoplasia (MEN)2 or von-Hippel Lindau syndrome (VHL) are more likely to be malignant and multiple. Recently the role of mutations in the SDH genes (encoding subunits of succinate dehydrogenase) have also been identified as important in the aetiology of such tumours. We report a case where identification of an apparently sporadic metastatic phaeochromocytoma was found to be co...

ea0011p568 | Growth and development | ECE2006

Growth hormone induced improvement in quality of life does not correlate with reduction in vascular risk in adult hypopituitary patients

McCallum RW , Petrie JR , Dominiczak AF , Connell JMC

Hypopituitary patients on conventional hormone replacement, excluding GH have a reduced quality of life (QoL) and an increased risk of cardiovascular mortality. NICE guidelines on criteria for initiation and maintenance of therapy rely on QoL score defined by the Adult GHD assessment (AGHDA) questionnaire. However, it is uncertain how this score is related to other biological effects such as vascular risk.Methods: Sixteen hypopituitary patients were recr...

ea0011p117 | Clinical case reports | ECE2006

Cushing’s disease presenting as a Schizophreniform psychosis

McCallum RW , Parameswaran V , Duffield A , Hoffman L , Burgess JR , Greenaway T

A number of psychiatric conditions are associated with CushingÂ’s disease. Acute psychosis is rare. We describe a patient with sudden onset of florid psychosis who required medical and surgical treatment.Case: A 38 year old woman previously well and employed in the financial sector was admitted to the acute psychiatric unit with delusional, disorganised and paranoid ideation. Despite management with olanzapine, haloperidol and benzodiazepines her men...