Searchable abstracts of presentations at key conferences in endocrinology

ea0011p387 | Diabetes, metabolism and cardiovascular | ECE2006

Androgen regulation of hepatic glucocorticoid metabolism in obese Zucker rats

Livingstone DEW , Barat P , McDonnell CR , Walker BR , Andrew R

Obesity is associated with decreased hepatic reactivation of glucocorticoids (Gc) by 11β-hydroxysteroid dehydrogenase type 1 (11HSD) and increased metabolism of glucocorticoids by hepatic A-ring reductases, which may contribute to activation of the hypothalamic-pituitary-adrenal axis. Androgen action encourages central obesity and increased metabolic complications, possibly by altering Gc metabolism.This study investigates the role of gonadal androg...