Endocrine Abstracts

Leptin is best known as an appetite and metabolic rate modulator secreted from fat, but it also has a range of other functions including modulation in reproductive physiology. To date, most studies examining the role of leptin in male reproduction have focussed on individual tissues, often in vitro. In the current report, a bolus physiological dose of iodinated leptin was administered intravenously to male mice to and samples collected over a one hour time course to d...

A 39 year-old man was referred with resistant hypertension from the nephrology service. Diagnosis was at 26 years and associated with hypokalaemia, left ventricular hypertrophy and proteinuria. Initial results (on amiloride) were: Aldosterone (A) 1900 pmol/l, direct renin (R) 10.2mU/mL and Aldosterone:Renin Ratio (ARR) 186. Saline suppression testing off interfering medications confirmed primary aldosteronism (PA): Aldosterone 1050 pmol/l, Renin 4.1uIU/mL and ARR 256 at four h...

Introduction: Graves’ disease during pregnancy may cause maternal or neonatal complications, including arrhythmia, thyroid storm, congenital anomalies and neonatal thyroid dysfunction (TD). The optimal timing and frequency of TRAb measurement in pregnant women with a history of TD, and whether fetal monitoring could be limited to those with a strongly positive TRAb, is unclear.Methods: Retrospective case note review of women with elevated TRAb (>1 i...