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Endocrine Abstracts

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ea0104p111 | Diabetes & Metabolism | SFEIES24

GPR120/GPR40 agonism activates downstream signalling molecules that improve beta cell function and insulin resistance in type 2 diabetes

McGinn Dearbhla , Owolabi Adeoluwa , Corbett Reece , Tarasov Andrei , Flatt Peter , McKillop Aine

Background: G-Protein Coupled Receptors-120 (GPR120) and GPR40 are of interest as targets for treating diabetes and obesity due to their involvement in incretin secretion. This study investigated the mechanistic function of dual agonism on regulating the regeneration of beta cell mass, proliferation, and the insulin secretory response, using CRISPR/Cas9 gene knockout cells and intracellular-signalling analysis.Methods: Clonal pancreatic BRIN-BD11 cells a...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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