Searchable abstracts of presentations at key conferences in endocrinology

ea0003p65 | Clinical Case Reports | BES2002

Is the Endocrine nurse too accessible?

Stewart S , McGregor E

In an attempt to audit one aspect of the endocrine nurse's workload, all incoming telephone calls to our office were monitored over a two month period.Details recorded were the call source, the query raised and the time taken by the nurse to respond appropriately. We went on to analyse the information gathered to ascertain areas where improved clinical practice could alleviate the need for further calls.Calls totalled 200 in the ...

ea0078dpd3.1 | Session 2 (1) | BSPED2021

Early Detection of Neonatal Diabetes

McGregor David , McDonald Tim , Moudiotis Chris

Neonatal Diabetes Mellitus (NDM) occurs in the neonatal period and has a very high burden of morbidity and mortality. The incidence is approximately 1:100,000 but reports range from between 1 in 25,000 to 1:500,000 live births. A genetic cause can be found in over 80% of cases. At present, patients with NDM are unrecognised as being seriously ill until hyperglycaemia is at a life-threatening level. An effective method for measuring blood glucose concentrations from Guthrie car...

ea0008p67 | Neuroendocrinology and behaviour | SFE2004


McGregor EJ , Jenkinson H , Griffiths A , Toogood AA

Acute lymphoblastic leukaemia is the commonest malignancy to occur during childhood. Treatment protocols included prophylactic cranial radiotherapy at doses of 18-24Gy. Radiation to the hypothalamic-pituitary axis causes hypopituitarism, the severity of which depends upon the dose and time from treatment. Adults who received 24Gy up to 25 years ago have been shown to be GH deficient, those who received 18Gy were not. Other pituitary function was reported be normal. The purpose...

ea0003p201 | Neuroendocrinology | BES2002

Outcome of treatment for Cushing's disease in Birmingham; the experience of a single surgeon

Dale J , McGregor E , Johnson A , Gittoes N

Transsphenoidal surgery (TSS) is the most common first-line treatment for Cushing's disease (CD). We have examined the outcome of this intervention to identify pre-operative clinical factors that predict good surgical outcome and to determine the risk of adverse events.We performed a case-notes review of 30 consecutive patients, 20 (67%) female, treated by a single surgeon over a 14-year period. The mean (SE) age was 34.2 (2.1) years and median (range) ...

ea0003p205 | Neuroendocrinology | BES2002

Outcomes in the management of pituitary apoplexy; a conservative approach may be prudent

McGregor E , Ayuk J , Gittoes N

Due to the infrequency of pituitary apoplexy, there are no robust evidence-based guidelines for optimum care of these patients. The key controversy surrounds the role of acute neurosurgical intervention. Over recent years we have adopted a relatively conservative approach and the aim of this study was to determine whether this 'non-intervention' affected long-term outcome in a recent cohort of patients. 19 patients (8 female) presented between 1994-2001. Mean age at diagnosis ...

ea0028p44 | Clinical practice/governance and case reports | SFEBES2012

Determining the utility of the 60 minute cortisol measurement in the short synacthen test

Chitale Aditi , Musonda Patrick , McGregor Alan , Dhatariya Ketan

Context: Despite the widespread use of the short synacthen test (SST), there remains no clear consensus on sampling times for the measurement of serum cortisol that best determines adrenal reserve.Objective: To establish whether there is any value in measuring serum cortisol at 60 minutes following administration of synacthen.Design and setting: Retrospective data analysis of 500 SST results measuring 0, 30 and 60 minute cortisol l...

ea0011p521 | Endocrine tumours and neoplasia | ECE2006

Outcome of management of craniopharyngiomas – a contemporary series

Rippin JD , Mitchell RD , McGregor EJ , Toogood AA , Gittoes NJ

The optimum management of patients with craniopharyngiomas is controversial. Evidence relies on a small number of retrospective outcome surveys that encompass time periods that are not necessarily representative of current surgical techniques and imaging modalities. We have reviewed outcome in a more contemporary group of patients managed at a single centre.Case-notes and electronic data were reviewed of all patients treated for craniopharyngioma since 1...

ea0010oc12 | Thyroid and pituitary | SFE2005

High frequency of abnormal GH suppression and subclinical acromegaly in a series of patients with thyrotropin-secreting pituitary adenoma

Pramodh S , #Gilbert|# , #Hepburn|# , #Chambers|# , #Al-Sarraj|# , #Mcgregor|# , #Aylwin|#

Background: Thyrotropin-secreting pituitary adenomas (TSH-omas) account for 1% of pituitary tumours. In addition to TSH, these tumours frequently secrete glycoprotein α-subunit (αSU) and up to 50% are immunoreactive for growth hormone (GH), although GH suppression following oral glucose tolerance testing (OGTT) has not been routinely performed in all patients to identify subclinical GH hypersecretion or abnormal GH suppression.Objectives: To ex...

ea0009oc19 | Oral Communication 3: Neuroendocrinology | BES2005

The nadir growth hormone after an octreotide test dose predicts the long term efficacy of somatostatin analogue therapy in acromegaly

Gilbert J , Miell J , Chambers S , McGregor A , Aylwin S

Treatment of acromegaly aims primarily to reverse the increased mortality and morbidity associated with active disease to that of the non-acromegalic population. Recent evidence indicates that the best biochemical criteria for successful treatment should be a mean GH<2micrograms per litre (approximately 4milliunits per litre). Although a 'test dose' of octreotide (OTD) is recommended prior to use of depot somatostatin analogues (SSAs), there remains no consensus regarding t...

ea0003p204 | Neuroendocrinology | BES2002

Growth hormone (GH) deficiency in adults treated for acute lymphoblastic leukaemia (ALL) in childhood

Ayuk J , McGregor E , Mann J , Stewart P , Toogood A

The number of patients treated for malignant disease in childhood surviving into adulthood is increasing, but success is tempered by long-term side-effects of chemotherapy and radiotherapy; 40% develop one or more endocrinopathy. ALL is a common childhood malignancy treated with chemotherapy and cranial irradiation. The latter causes anterior pituitary hormone deficiencies, most frequently GH deficiency.We have determined GH status in 13 patients treate...