Searchable abstracts of presentations at key conferences in endocrinology

ea0077cc4 | (1) | SFEBES2021

Kennedy’s Disease: An uncommon cause of androgen insensitivity and motor neuropathy

Roulston Gary , McConville John , McHenry Claire

Kennedy’s Disease (KD) or Spinal and Bulbar Muscle Atrophy is a rare X-linked recessive condition due to CAG repeat in the androgen receptor (AR) gene. KD affects males with unaffected female carriers. Reported prevalence in male populations is highly variable; recent data suggests 2.5 in 100,000 with region specific higher prevalence. KD manifests as androgen insensitivity (AI) with features including gynaecomastia and motor signs such as early tremor, facial an...

ea0086p131 | Thyroid | SFEBES2022

Therapeutic database of anti-thyroid medication over 10 years in northern ireland (NI) 2010-2019: trends, demographics and deprivation

Kayes Lucy , McHenry Claire , Woodside Jayne , Mullan Karen

Anonymised therapeutic data has been available for all patients in NI across 364 general practices since 2008. The database records age, gender, trusts and postcodes, which allows for spatial deprivation analyses. Patients were categorised in deciles (1-most deprived, 10-least) according to published criteria. We examined carbimazole (CBZ) and propylthiouracil (PTU) prescriptions over 10 years (2010 to 2019). Patients treated definitively with surgery/radioiodine are invariabl...

ea0031p18 | Bone | SFEBES2013

Predictors of low bone mineral density in an Irish cystic fibrosis (CF) cohort

McEnery Tom , Glynn Nigel , Gunaratnam Cedric , McElvaney Noel , Smith Diarmuid , McHenry Claire

Increased life expectancy in patients with CF has brought about novel challenges in their care. Osteoporosis in CF is associated with significant morbidity and is an exclusion criterion for lung transplantation. Recent evidence suggests an association between dysglycaemia and low bone mineral density (BMD). We aimed to determine predictors of bone loss in a cohort of CF patients attending a tertiary referral centre and, in particular, if dysglycaemia is linked with low BMD.</p...

ea0031p21 | Bone | SFEBES2013

The utility of neck MRI in the localisation of parathyroid adenomas in primary hyperparathyroidism

Glynn Nigel , Pierce Brian , Hill Arnold DK , McHenry Claire , Smith Diarmuid , Thompson Chris , Keeling Frank , Agha Amar

Neck ultrasound (US) can facilitate minimally invasive parathyroidectomy by providing fine anatomical detail of enlarged parathyroid adenomas in patients with primary hyperparathyroidism (PHPT). The role of neck MRI in US negative/equivocal cases remains unclear. We aimed to evaluate the performance of neck MRI in parathyroid tumour localisation in the setting of negative or equivocal neck US.We performed a retrospective review of a consecutive series of...

ea0021p295 | Pituitary | SFEBES2009

Effects on insulin action of dehydroepiandrosterone sulphate replacement in hypopituitary females

McHenry Claire , Bell Patrick , Hunter Steven , Thompson Christopher , Courtney Hamish , Ennis Cieran , Sheridan Brian , McCance David , Mullan Karen , Atkinson Brew

Hypopituitary patients are at increased vascular risk. This may be partly attributable to changes in insulin action. It has been suggested that the addition of dehydroepiandrosterone sulphate (DHEAS), which is low in patients with secondary hypoadrenalism, to routine replacement may have beneficial effects on glucose metabolism. Previously, patient populations and techniques used to assess insulin action varied and overall results have been conflicting.W...

ea0031p364 | Thyroid | SFEBES2013

Clinical performance of fine-needle aspiration biopsy of thyroid nodules in a tertiary referral centre

Glynn Nigel , Hannon Mark , Lewis Sarah , Hillary Patrick , Hill Arnold D K , Keeling Frank , Morrin Martina , McHenry Claire , Smith Diarmuid , Thompson Chris , Leader Mary , Agha Amar

Fine-needle aspiration biopsy (FNAB) is the tool of choice for evaluating thyroid nodules but there is a significant percentage of insufficient or indeterminate aspirates and falsely reassuring results have been reported in up to 6% of cases.We aimed to examine our experience with FNAB among a large cohort of unselected patients with thyroid nodules.239 consecutive patients (211 women) underwent FNA of a thyroid nodule between July...