Searchable abstracts of presentations at key conferences in endocrinology

ea0028p315 | Steroids | SFEBES2012

Suppression of adrenal cortisol metabolism by type 2 11β-hydroxysteroid dehydrogenase enzyme (11βHSD2) in the luteal phase of the ovine oestrous cycle

Tennant Laura , McIlvride Saraid , Abayasekara Dilkush , Michael Anthony

We have previously investigated the ability of glucocorticoids secreted by the adrenal cortex to directly influence gonadal function. In contrast, the primary aim of the present study was to assess whether increased progesterone output from the corpus luteum on day 14 of the ovine oestrous cycle can alter adrenal metabolism (and hence output) of cortisol relative to oestrous cycle day 5. Since cortisol-cortisone inter-conversion by the cloned 11β-hydroxysteroid dehydrogen...

ea0038p233 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Brown adipose tissue plays a role in regulating fetal growth by undergoing a gestational-dependent phenotypic change

McIlvride Saraid , Abu-Hayyeh Shadi , Papacelovoulou Georgia , Jansen Eugene , Steel Jennifer , Maragkoudaki Xanthi , Williamson Catherine

Pregnancy is associated with increased maternal plasma lipid levels, an important physiological response to support the nutritional demand of the developing fetus and mother. The homeostatic controls of metabolically active organs are known to change in response to pregnancy signals. We hypothesised that pregnancy affects brown adipose tissue (BAT) phenotype and function and as a consequence plays a role in the regulation of fetal development and growth....

ea0028p316 | Steroids | SFEBES2012

Impact of prenatal androgens on glucocorticoid metabolism in an ovine model of PCOS.

McIlvride Saraid , Ellison Alicia , Hogg Kirsten , McNeilly Alan , Duncan Colin , Michael Anthony

Within target cells, cortisol-cortisone inter-conversion is catalysed by both a NADP(H)-dependent, bidirectional type 1 11β-hydroxysteroid dehydrogenase (11βHSD1) enzyme and by a NAD+-dependent, unidirectional type 2 11βHSD (11βHSD2) isoenzyme. Since several published studies have reported altered glucocorticoid metabolism in polycystic ovary syndrome (PCOS), the current study assessed whether prenatal exposure of lambs to testosterone propionate...