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ea0091oc1 | Oral Communications | SFEEU2023

‘Pseudo-failure’ of adrenal vein sampling due to cortisol co-secretion by KCNJ5-mutant adenoma, and prediction of complete clinical success by urine hybrid steroid assay

Laycock Kate , Wu Xilin , Goodchild Emily , Matson Matthew , Prete Alessandro , Taylor Angela , Arlt Wiebke , McIntosh Alasdair , McConnachie Alexander , Cheow Heok , Drake William , Brown Morris

Case history: A previously well 45-year-old lady presented with a 3-year history of hypertension initially diagnosed at a routine health check. Her blood pressure (BP) was 170-180/90-100 mmHg.Investigations: Showed hypokalaemia (K+= 3 mmol/l; NR 3.5-5.3 mmol/l), raised aldosterone (976pmol/l; NR 100-500pmol/l) and supressed renin activity (<0.2nmol/l/h), meeting criteria for diagnosing primary aldosteronism (PA). CT adrenals showed a 2.5 cm left adre...

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ea0073oc1.5 | Oral Communications 1: Adrenal and Cardiovascular Endocrinology | ECE2021

Primary results from MATCH: A randomised controlled trial in primary aldosteronism

Wu Xilin , Senanayake Russell , Goodchild Emily , Bashari Waiel , Salsbury Jackie , Argentesi Giulia , O’Toole Samuel , Matson Matthew , Parvanta Laila , Marker Alison , Berney Daniel , Sahdev Anju , Bird Nicholas , McConnachie Alexander , McIntosh Alasdair , Laycock Kate , Cruickshank Kennedy , Cheow Heok , Gurnell Mark , Drake William , Brown Morris

Primary aldosteronism (PA) is considered the sole, often curable, cause of hypertension in 5–10% of patients. Yet there has been only one RCT, and practice has changed little since the advent of CT scanning. Adrenal vein sampling (AVS) and adrenalectomy remain the standard, invasive interventions, leading to a 50% reduction in pill count as the average clinical improvement.Study DesignIn MATCH (Is Metomidate PET-CT superior t...

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Endocrine Abstracts

‘Pseudo-failure’ of adrenal vein sampling due to cortisol co-secretion by KCNJ5-mutant adenoma, and prediction of complete clinical success by urine hybrid steroid assay

Primary results from MATCH: A randomised controlled trial in primary aldosteronism

BiosciAbstracts