Searchable abstracts of presentations at key conferences in endocrinology

ea0015s13 | System-specific effect steroids | SFEBES2008

Glucocorticoid signalling in the brain

Lightman Stafford , Atkinson Helen , Droste Susanne-Katrin , Harbuz Michael , de Kloet Ronald , Linthorst Astrid , McKenna Mervyn , Reul Johannes , Seale Josephine , Wiles Crispin , Wood Susan , Conway-Campbell Becky

Aims: To define the ultradian pattern of corticosterone secretion in the rat, how this may be altered in different physiological states and the relevance of these patterns to nuclear signalling in the hippocampus.Methods: Rats were cannulated and attached to our automated blood sampling system. Some rats had simultaneous intracranial microdialysis for free corticosterone in the hippocampus and other rats were adrenalectomised and corticosterone replaced ...