ea0015p303 | Steroids | SFEBES2008
McNeilly AD
, Livingstone DEW
, McKenzie SM
, Davies E
, Skott O
, Thiesson H
, Kenyon CJ
, Walker BR
, Andrew R
Glucocorticoids mediate the stress response, regulated via the hypothalamicpituitaryadrenal (HPA) axis. The HPA axis is down-regulated and its responsiveness to stress is impaired in cholestasis. The mechanisms are unknown, but may involve reduced glucocorticoid clearance. Hepatic 5beta-reductase is involved in glucocorticoid inactivation and bile acid biosynthesis. We showed previously that bile acids are potent competitive inhibitors and transcriptional regulator...