Searchable abstracts of presentations at key conferences in endocrinology

ea0037gp.05.02 | Developmental and paediatric endocrinology | ECE2015

The differential impact of PAPS synthase isoforms on DHEAS may be explained by an isoform-specific interaction of SULT2A1 with PAPSS2, but not PAPSS1

Mueller Jon W , Idkowiak Jan , Hardman Rebecca E , House Philip J , McNelis Joanne C , Rose Ian T , Dhir Vivek , Rosta Edina , Arlt Wiebke

Human sulfation depends on provision of the universal sulfate donor PAPS by the two PAPS synthase isoforms PAPSS1 and PAPSS2. Mutations in PAPSS2 have been identified as a monogenic cause of androgen excess presenting with premature adrenarche and polycystic ovary syndrome, due to decreased sulfation of the androgen precursor DHEA by DHEA sulfotransferase (SULT2A1) and hence increased conversion of DHEA to active androgens (New Eng J Med 2009 360 (22)...