Searchable abstracts of presentations at key conferences in endocrinology

ea0063s6.1 | A better life with thyroid hormone (Endorsed by the European Journal of Endocrinology) | ECE2019

Prediction of the thyroid axis set-point

Medici Marco

In the last few years studies have shown that subtle variations in thyroid function, including subclinical thyroid dysfunction, and even variation in thyroid function within the normal range, are associated with morbidity and mortality. It is estimated that 40–65% of the inter-individual variation in serum TSH and FT4 levels is determined by genetic factors. To identify these factors, various linkage and candidate gene studies have been performed in the past, which have i...

ea0041oc4.1 | Thyroid - Clinical | ECE2016

Additional measurement of hCG distinguishes physiological high-normal thyroid function and reveals large differences in the risk of developing preeclampsia

Korevaar Tim , Steegers Eric , Medici Marco , Visser Theo , Peeters Robin

Context: Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality worldwide, affecting 2–8% of all pregnancies. We have previously shown that women with high-normal levels of FT4 during early pregnancy have a 2.1-fold increased risk of preeclampsia – but there was no apparent association with low TSH. However, the thyroid is stimulated by human chorionic gonadotropin (hCG) during early pregnancy and therefore we hypothesized that women with h...

ea0037gp.27.06 | Thyroid – hyperthyroidism and treatment | ECE2015

hCG levels are essential for the correct interpretation of gestational TSH levels: the clinical risk assessment of premature delivery

Korevaar Tim , Medici Marco , Chaker Layal , Tiemeier Henning , Visser Theo , Peeters Robin

Context: High maternal TSH and/or low FT4 during pregnancy is associated with an increased risk of premature delivery. hCG is the main determinant of thyroid function changes during pregnancy but has a versatile pattern with high inter and intra-individual variability. We hypothesised that the correct interpretation of thyroid function tests and its use in the risk assessment of premature delivery during pregnancy depend on hCG levels.Design, ...

ea0092ps2-20-03 | Thyroid hormone receptors basic | ETA2023

Epigenome-wide association study reveals cpg sites associated with thyroid function and regulatory effects on KLF9

Weihs Antoine , Chaker Layal , Martin Tiphaine , Bell Jordana , Medici Marco , Teumer Alexander

Thyroid hormones play a key role in cellular growth, development, and metabolism, and are known regulators of gene expression through genomic and non-genomic processes including DNA methylation. Using eight cohorts from the ThyroidOmics-Consortium and a standardized meta-analysis quality control pipeline, we conducted an epigenome-wide association study between blood-based leucocyte DNA methylation sites and thyroid hormones (TSH, free T3 and free T4) in up to 7,073 participan...

ea0092op-10-01 | Oral Session 10: Novel diagnostics in Thyroid cancer | ETA2023

Identification of clinical and histopathological risk factors for radioactive iodine refractory disease in patients with follicular and hurthle cell thyroid carcinoma

Stegenga Merel , Oudijk Lindsey , Van Velsen Evert , Medici Marco , Peeters Robin , Edward Visser W. , van Kemenade Folkert

Introduction: Historically, treatment of follicular thyroid carcinoma (FTC) and oncocytic thyroid carcinoma (OTC) is based on thyroidectomy followed by radioiodine (RAI) therapy. Both tumor types have a good prognosis (10-year survival 80-94%), but this changes significantly once RAI-refractory disease occurs (median 3.5 years), which limits further treatment possibilities. The main risk factors for developing RAI-refractory disease in FTC and OTC are unknown. Our aim was to i...

ea0092op-05-04 | Oral Session 5: Young Investigators / Basic | ETA2023

Multi-Trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications

Sterenborg Rosalie , Steinbrenner Inga , Li Yong , Bujnis Melissa , Naito Tatsuhiko , Marouli Eirini , Consortium Thyroidomics , Kottgen Anna , Smit Johannes W.A. , Peeters Robin , Teumer Alexander , Medici Marco

Introduction: In the last decade, it has become clear that not only overt but also subclinical hypo- and hyperthyroidism are associated with several adverse clinical outcomes, including atrial fibrillation, coronary heart disease, stroke and mortality. More recently, various studies have suggested that even small differences in thyroid function within the reference range are associated with clinical consequences. Genetic factors are responsible for up to 58-71% of the variatio...

ea0084op-11-58 | Oral Session 11: Young Investigators / Basic | ETA2022

Integrated genomic, phenomic, functional and structural mapping of variants in thyroid hormone transporter MCT8

Groeneweg Stefan , Van Geest Ferdy , martin mariano , Dias Mafalda , Frazer Jonathan , Sterenborg Rosalie , de rooij linda , dolcetta-capuzzo anna , teumer alexander , Meima Marcel , Medici Marco , pablo nicola juan , marks debora , Edward Visser W.

Background: MCT8 deficiency is caused by loss-of-function (LoF) mutations in thyroid hormone (TH) transporter MCT8. Patients have developmental delay and abnormal thyroid function tests (TFTs). The large phenotypic variability is not understood. Moreover, phenotypes arising from LoF mutations could be employed to enhance understanding of physiology in the general population. Also, computational disease variant classifiers have poor predictive power to ascertain impact of MCT8 ...

ea0034oc1.3 | Young Endocrinologists prize session | SFEBES2014

Angiogenic factors sFlt1 and PlGF are novel determinants of newborn thyroid (dys)function: the Generation R Study

Korevaar Tim , Schalekamp-Timmermans Sarah , Visser Theo , de Rijke Yolanda , Visser Edward , Visser Willy , de Muinck Keizer-Schrama Sabine , Hofman Albert , Hooijkaas Herbert , Tiemeier Henning , Bongers-Schokking Jacoba , Jaddoe Vincent , Steegers Eric , Medici Marco , Peeters Robin

Introduction: Adequate thyroid hormone availability during early life is crucial for normal child growth and development. Fetal growth in utero heavily depends on angiogenesis. Placental growth factor (PlGF) is a proangiogenic factor sharing high homology with vascular endothelial growth factor (VEGF) whereas soluble FMS-like tyrosine kinase-1 (sFlt1) is a potent antagonist of VEGF and PlGF signaling. Since the thyroid is a highly vascularized organ, we hypothesized t...

ea0084op-06-28 | Oral Session 6: Hypothyroidism | ETA2022

The optimal ranges of thyroid function based on the risk of cardiovascular disease and mortality: an individual participant data meta-analysis

Xu Yanning , Derakhshan Arash , Wildisen Lea , Hysaj Ola , Iacoviello Massimo , Ceresini Graziano , Ferrucci Luigi , Iervasi Giorgio , Pingitore Alessandro , Vaes Bert , Gussekloo Jacobijn , Medici Marco , Galesloot Tessel , P. F. Dullaart Robin , J.L. Bakker Stephan , Wouter Jukema J. , Trompet Stella , Westendorp Rudi , Ittermann Till , Volzke Henry , Dorr Marcus , Schmidt Borge , Fuhrer Dagmar , J. Wareham Nicholas , Boelaert Kristien , Razvi Salman , P. J. Vanderpump Mark , Muendlein Axel , Drexel Heinz , Bensenor Isabela , Sgarbi Jose , C. Bauer Douglas , A. Fink Howard , M. Rhee Connie , Azizi Fereidoun , Imaizumi Misa , B. Yeap Bu , Hankey Graeme , J. Brown Suzanne , P. Walsh John , Korevaar Tim , Rodondi Nicolas , R. Cappola Anne , Peeters Robin , Chaker Layal , the Thyroid Studies Collaboration for

Background and Objective: Thyroid function reference ranges are statistically defined by the 2.5th and 97.5th percentiles, which do not account for potential risk of clinical outcomes. We aimed to define the optimal ranges of thyroid-stimulating hormone (TSH) and free thyroxine (FT4), based on the risk of cardiovascular disease (CVD) and mortality.Methods: We performed an individual-participant data analysis and identified prospecti...