Searchable abstracts of presentations at key conferences in endocrinology

ea0022p223 | Clinical case reports and clinical practice | ECE2010

Hypoparathyroidism related epilepsy

Alves Marta , Neves Celestino , Carvalho-Braga Daniel , Medina Jose Luis

Background: Permanent hypoparathyroidism can result from immune-mediated destruction of the parathyroid glands. Alternatively it may result from activating antibodies to the calcium sensing receptor that decrease parathyroid hormone (PTH) secretion. Autoimmune hypoparathyroidism is a common feature of poliglandular autoimmune syndrome type I. Other causes, all very rare, include irradiation and storage of infiltrative diseases of the parathyroid glands. Neurological signs of h...

ea0020p308 | Clinical case reports and clinical reports | ECE2009

Hypergonadotropic hypogonadism due to vanishing testis syndrome: case report

Souto Selma B , Carvalho-Braga Daniel , Medina Jose Luis

Introduction: Anorchia or vanishing testis syndrome is defined as the absence of testicular tissue in genetic and phenotypic males. To establish this diagnosis certain criteria must be present, namely non palpable testis during examination under anaesthesia and blind ending spermatic vessels visualized within the retroperitoneu, or the spermatic vessels and vas deferens exiting a closed internal inguinal ring. Bilateral congenital anorchia affects one in 20 000 males.<p cl...

ea0081p469 | Thyroid | ECE2022

Graves’ disease and polymorphisms in proinflammatory cytokines genes

Neves Celestino , Neves Joao Sergio , Goncalves Juliana , Soares Paula , Luis Medina Jose , Carvalho Davide

Background: Graves’ Disease (GD) is one of the most common organ specific autoimmune disorders, being characterized by an abnormal production of stimulating autoantibodies to the thyrotropin receptor (TSHR). Some studies demonstrated that genetic polymorphisms in certain cytokines, namely interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), are associated with a greater susceptibility of developing GD. Our aim was to evaluate ...

ea0035p1017 | Thyroid (non-cancer) | ECE2014

Adipokines and cardiovascular risk factors in patients with autoimmune thyroiditis and subclinical hypothyroidism

Neves Celestino , Esteves Cesar , Sokhatska Oksana , Palmares Carmo , Carvalho Davide , Delgado Luis , Medina Jose Luis

Aim: To evaluate the serum levels of resistin and adiponectin, and the potential relationship between these adipokines, thyroid function, lipid profile, C-reactive protein (CRP) and homocysteine levels in patients with autoimmune thyroiditis (AIT) and subclinical hypothyroidism (SCH).Methods: patients with AIT (58 females; 47.7±16.7 years) were studied; 33 of them had also SCH. These patients were diagnosed by a positive result in an anti-peroxidase...

ea0022p227 | Clinical case reports and clinical practice | ECE2010

Hypogonadotropic hypogonadism in POEMS syndrome – case report

Rodrigues Pedro , Castedo Jose Luis , Rocha Madalena , Guimaraes Patricia , Guimaraes Jose Eduardo , Medina Jose Luis

Introduction: POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) syndrome is a rare multisystemic disease. Diagnosis requires two major criteria and at least one minor criterion. Major criteria include polineuropathy and a monoclonal plasma proliferative disorder (almost always lambda). Minor criteria include osteosclerotic bone lesions, Castleman disease, organomegaly (including lymphadenopathy), oedema, pleural effusion or ascites, e...

ea0022p228 | Clinical case reports and clinical practice | ECE2010

Cushing's syndrome as presentation of an ACTH-producing pulmonary tumour

Rodrigues Pedro , Castedo Jose Luis , Cernadas Eduardo , Carvalho Davide , Medina Jose Luis

Introduction: Ectopic Cushing’s syndrome is a rare disease, with a reported incidence of 0.1/million per year. This disorder accounts for approximately 12–17% of patients with ACTH-dependent Cushing’s syndrome. Small cell lung carcinoma is responsible for about 20% of cases, although ectopic ACTH hypersecretion occurs in only 0.5–2% of these tumours. Hypercortisolaemia is usually severe and of rapid onset. Optimal treatment is surgical excision of the tumou...

ea0022p862 | Thyroid | ECE2010

Clinical and histopathologial characteristics of papillary thyroid microcarcinoma (PTMC)

Rodrigues Elisabete , Sousa Ana , Lima Luis Matos , Pimenta Amadeu , Medina Jose Luis

Introduction: The recognition of thyroid microcarcinoma has been increasing in recent years probably as a result of the widespread use of ultrasound-guided fine-needle aspiration biopsies (FNAB) of small non palpable nodules and possibly of a more extensive histological examination.Objectives: To describe clinical and histological characteristics of papillary thyroid microcarcinoma and compare them according to its size (< or ≥5 mm).<p clas...

ea0020p413 | Diabetes and Cardiovascular | ECE2009

Quality of life in diabetes mellitus: conditional issues of treatment and coping strategies

Pereira Miguel , Neves Celestino , Pereira Joao , Carqueja Eduardo , Alves Marta , Carvalho Davide , Coelho Rui , Medina Jose

Introduction: Quality of life (QoL) is a subject of increasing interest in the health context. Applied to a chronic condition like diabetes, this issue could give an overall perspective of the health outcome.Objective: To evaluate the coping mechanisms, the treatment issues and its contribution to QoL of diabetes patients.Patients and methods: We gathered a sample of 94 diabetic subjects, 50% males, 55.3% type 1, with a mean age of...

ea0041gp197 | Thyroid - Basic | ECE2016

Evaluation of interrelations between resistin, adiponectin, PAI-1, intercellular adhesion molecule and thyroid function in autoimmune thyroid disease

Neves Celestino , Neves Joao Sergio , Oliveira Sofia Castro , Esteves Cesar , Sokhatsha Oksana , Delgado Luis , Medina Jose Luis , Carvalho Davide

Introduction: Given the significant impact of thyroid function on body weight, energy metabolism and adipocytes physiology, our aim was to study the impact of subclinical thyroid dysfunction in plasmatic levels of adipokines and ICAM-1 (intercellular adhesion molecule 1).Methods: We evaluated 98 patients with autoimmune thyroid disease divided into three groups: 30 who were euthyroid (TSH=0.35–4.94 UI/ml), 35 with subclinical hypothyroidism (hypoSC,...

ea0032p1065 | Thyroid (non-cancer) | ECE2013

Subclinical autoimmune thyroid disease and cardiovascular risk factors

Neves Celestino , Esteves Cesar , Pereira Miguel , Palmares Carmo , Sokhatsha Oksana , Dias Camila , Delgado Luis , Carvalho Davide , Luis Medina Jose

Objective: To examine whether Graves’ disease (GD) and autoimmune thyroiditis (AIT) are associated with insulin resistance and other cardiovascular risk factors.Subjects and methods: We recorded thyroid function tests, BMI, insulin resistance markers comprising the homeostasis model assessment for insulin resistance (HOMA-IR and HOMA-B), the quantitative insulin sensitivity check index (QUICKI), hepatic insulin sensitivity index (HISI), whole-body i...