Searchable abstracts of presentations at key conferences in endocrinology

ea0011s36 | Clinical lessons from novel aspects of G protein-coupled receptors signalling | ECE2006

Moleular pathology of the FSH receptor

Vasseur C , Rodien P , Meduri G , Touraine P , Lahuna O , Kuttenn F , Misrahi M

The identification of naturally occurring genetic mutations of the FSH receptor has led to a better understanding of the role of FSH in folliculogenesis and has allowed to identify the cause of several syndroms. Inactivating mutations of the follicle stimulating hormone (FSH) receptor have been described in rare cases of premature ovarian failure (POF). We have studied a new patient presenting a complete POF phenotype, with high plasma FSH levels, very low estrogen and inhibin...

ea0011p723 | Reproduction | ECE2006

Isolated progesterone secretion by an ovarian Leydig cell tumour: I, hormonal and immunohistochemical characterization II, effects on the gonadotrope axis

Bry H , Meduri G , Abirached F , Constancis E , Brailly S , Chanson P , Young J

A 20 yr old woman was referred for primary amenorrhea. At examination BMI was 19 and displayed a pubertal development at S4P4. Hormonal evaluation showed normal prolactin, low estradiol (18 pg/ml) and gonadotropins (LH=1.5IU; FSH=1.9 IU/L). Testosterone was normal (0.25 ng/ml) but curiously plasma progesterone (P) was increased (from 3.9 to 5 ng/ml). Initial ovarian sonography and adrenal CT scan didn’t show any abnormal mass. ACTH stimulation tests showed normal response...