Searchable abstracts of presentations at key conferences in endocrinology

ea0073aep89 | Calcium and Bone | ECE2021

Normalization of SIAD-induced hyponatremia stimulates osteoblast function

Potasso Laura , Refardt Julie , Meier Christian , Christ-Crain Mirjam

BackgroundHyponatremia is associated with increased risk of bone fragility and fractures. In vitro studies suggest a role of hyponatremia in stimulating osteoclast activation, whereas other studies rather revealed a possible role of acute hyponatremia in impairing osteoblast function. We aimed to assess whether and how correction of hyponatremia in hospitalized patients with the syndrome of inappropriate antidiuresis (SIAD) has an impact on bone...

ea0090p32 | Calcium and Bone | ECE2023

Plasma Sodium Increase Is Associated With an Increase in Bone Formation in Outpatients With Chronic SIAD - A Predefined Secondary Analysis of the SANDx Trial

Monnerat Sophie , Refardt Julie , Potasso Laura , Meier Christian , Christ-Crain Mirjam

Introduction: Hyponatremia is the most common electrolyte disorder encountered in clinical practice and is associated with increased mortality and morbidity, including an increased risk for osteoporosis and fragility fractures. Preclinical studies suggest osteoclast upregulation whereas a clinical study showed improved osteoblast fuction after hyponatremia normalization in hospitalized patients with SIAD.Methods: This is a secondary analysis of a double-...

ea0020p227 | Bone/Calcium | ECE2009

Experience with cinacalcet in primary hyperparathyroidism: results from the Swiss primary hyperparathyroidism cohort study

Meier Christian , Trombetti Andrea , Henzen Christoph , Rohrer Andreas , Hermann F , Braendle Michael , Christ Emanuel , Rizzoli Rene , Kraenzlin Marius

Objective: Cinacalcet, a calcimimetic that reduces parathyroid hormone (PTH) secretion and serum calcium (S-Ca) levels by increasing the sensitivity of calcium-sensing receptors has been introduced for the treatment of patients with persistent or recurrent primary hyperparathyroidism (PHPT). Within a prospective, non-interventional cohort study we identified patients with newly diagnosed PHPT who have been started on cinacalcet. Patient characteristics, treatment indications a...

ea0020p229 | Bone/Calcium | ECE2009

Swiss primary hyperparathyroidism cohort study

Trombetti Andrea , Meier Christian , Kraenzlin Marius E , Herrmann Francois R , Henzen Christoph H , Christ Emmanuel R , Brandle Michael , Rizzoli Rene

Objective: The Swiss Primary HyperParaThyroidism (PHPT) Cohort Study is an ongoing, prospective, non-interventional project collecting clinical, densitometric, biochemical and outcome data in patients with PHPT. The aims are to describe the profile of these patients particularly neurobehavioral and cognitive symptoms, changes in calcium and PTH over time and treatment modalities.Methods: Patients newly diagnosed with PHPT and with high serum calcium leve...