Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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ea0021p360 | Steroids | SFEBES2009

Replicated association of regions at CYP11B1/B2 locus with hypertension in Caucasians

Alvarez-Madrazo Samantha , Padmanabhan Sandosh , Friel Elaine , MacKenzie Scott , Brown Morris , Caulfield Mark , Munroe Patricia , Farrall Martin , Webster John , Samani Nilesh , Dominiczak Anna , Melander Olle , Davies Eleanor , Connell John

The locus comprising the genes that catalyse the final steps of cortisol and aldosterone synthesis (CYP11B1 and CYP11B2 respectively) is a plausible candidate risk region for hypertension and other cardiovascular diseases. Nevertheless, there remains uncertainty as to the strength of the relationship between polymorphisms at this locus and increased blood pressure. In this study, association with hypertension at the CYP11B1/CYP11B2 locus in a Caucasian cas...

ea0070oc3.3 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Circulating follistatin predicts type 2 diabetes risk

Wu Chuanyan , Borné Yan , Gao Rui , López Rodriguez Maykel , Roell William , Wilson Jonathan , Ahlqvist Emma , Luan Cheng , Peter Andreas , Machann Jürgen , Hong Mun-Gwan , Schwenk Jochen , Nilsson Peter , Shore Angela , Khan Faisel , Natali Andrea , Melander Olle , Orho-Melander Marju , Nilsson Jan , Renström Erik , Wollheim Claes , Pearson Ewan , Franks Paul , White Morris , Duffin Kevin , Vaag Allan , Laakso Markku , Stefan Norbert , Groop Leif , De Marinis Yang

Follistatin is a hepatokine found to be elevated in patients with type 2 diabetes (T2D) and promotes hyperglycemia in mice. We report that elevated baseline circulating follistatin levels predict future T2D incidence in longitudinal cohorts including up to 5274 individuals. Individuals with elevated circulating follistatin had higher risk of developing type 2 diabetes during follow-up of 4 years (IMI-DIRECT-METSIM, n = 1079, Finland), 5 and 19 years (MDC-CC, n...

Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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