Searchable abstracts of presentations at key conferences in endocrinology

ea0011p703 | Reproduction | ECE2006

Obstetric hazards of maternal obesity

Paiva S , Ruas L , Campos M , Melo M , Guimarães J , Lobo A , Sobral E , Marta E , Cravo A , Carvalheiro M

Introduction and objective: Prevalence of obesity is increasing in fertile women. We aimed to investigate its relation with pregnancy outcome.Methods: A retrospective analysis of 37 obese pregnant women (O group) was undertaken in the Endocrinology/Obstetric Unit, from 1998 to 2004. Control group included 33 pregnant women (C group) with normal body mass index (BMI).Results: Our O and C groups were age matched (O: 27.9±4.35; C...

ea0026p648 | Clinical case reports | ECE2011

How differentiated can a poorly differentiated thyroid cancer be? A rare case presenting with hyperthyroidism and secondary adrenal insufficiency

Melo M , Carrilho F , Ribeiro C , Carvalheiro M

Introduction: Poorly differentiated thyroid cancers are usually aggressive tumors that lack many of the characteristics of differentiated thyroid tissue, including the ability to uptake and process iodine.Case report: A 75-year-old male presented with weight loss, tiredness, asthenia, tremor, increased perspiration, tachycardia and bone pain in several locations. A hard and fixed thyroid nodule was palpable in the left lobe (FNA-«follicular tumor&#1...

ea0026p451 | Thyroid cancer | ECE2011

Recombinant tsh-stimulated thyroglobulin measurements in patients with differentiated thyroid carcinoma with basal thyroglobulin <1 ng/ml

Vieira A , Carrilho F , Ribeiro C , Melo M , Alves M , Gouveia S , Saraiva J , Carvalheiro M

Introduction: A value of thyroglobulin (Tg) undetectable under treatment with levothyroxine (LT) does not exclude residual/metastatic disease; this can be found in 18–35% of patients after recombinant TSH-stimulated Tg (sTg) measurements.Objective: Evaluating the role of recombinant TSH-stimulated thyroglobulin (sTg) measurements in patients with differentiated thyroid carcinoma, treated with suppressive LT doses, with basal Tg (bTG)<1 ng/ml.</p...

ea0011p130 | Clinical case reports | ECE2006

Adult-onset nesidioblastosis- a rare clinical case

Martins T , Gomes L , Guimarães J , Melo M , Carvalheiro M

Introduction: Nesidioblastosis is a rare but well recognized disorder of persistent hyperinsulinemic hypoglycemia in infancy, but adult-onset nesidioblastosis associated with hyperinsulinemic hypoglycemia, termed noninsulinoma pancreatogenous hypoglycemia syndrome (NIPHS) has also been reported. These patients experience predominantly postprandial hypoglycaemia instead of fasting hypoglycaemia that characterizes insulinoma. Histological findings are islet hypertrophy islet-cel...

ea0011p888 | Thyroid | ECE2006

Transcriptomic analysis of the oncocytic signal in vesicular thyroid tumours

Fontaine JF , Savagner F , Melo M , Ballester B , Houlgatte R , Malthièry Y

Vesicular thyroid tumours evolve from benign to malignant states, respectively called adenomas and carcinomas by respect to the World Health Organisation classification. Borderline cases, atypical adenomas, cannot be clearly classified. When an abnormal cytoplasmic mitochondrial proliferation occurs into the tumour cells, these tumours called oncocytomas, are more aggressive. Oncogenic mechanisms and signal pathways of these tumours are not well known and the origin of the onc...

ea0029p719 | Diabetes | ICEECE2012

Continuous subcutaneous insulin infusion systems: experience in 92 patients with type 1 diabetes

Saraiva J. , Carrilho F. , Barros L. , Batista C. , Melo M. , Gomes L. , Vieira A. , Alves M. , Gouveia S. , Moreno C. , Carvalheiro M.

Background: Continuous subcutaneous insulin infusion (CSII) using an external pump is an alternative intensive diabetes therapy recognized to improve metabolic control and glycemic instability in selected type 1 diabetic (T1DM) subjects. The aim of this study was to examine the clinical effectiveness and safety of CSII systems over a 5-year follow-up period in T1DM patients.Materials and methods: We performed a retrospective observational study of T1DM p...

ea0011p331 | Diabetes, metabolism and cardiovascular | ECE2006

Effects of weight loss on the coronary risk profile in obese patients two years after bariatric surgery

Melo M , Rodrigues D , Campos MV , Guimaraes J , Fagulha A , Figueiredo J , Manso C , Tralhão G , Milheiro A , Castro e Sousa F , Carvalheiro M

Objective: To analyse the effects of bariatric surgery on the global coronary risk profile two years after the surgical procedure.Methods: A total of 32 class III obese patients, 6 men and 26 women, mean age 34.3±8.5 years, were included. Total Cholesterol (TC), HDL, triglycerides, Blood Pressure (BP), presence of diabetes and smoking were evaluated before and two years after bariatric surgery. The 10 year Framingham coronary heart disease risk scor...

ea0026p484 | Thyroid cancer | ECE2011

Seventh UICC/TNM staging criteria for medullary thyroid carcinoma: is there any prognostic advantage?

Martinho M , Azevedo T , Carrilho F , Martins T , Ribeiro C , Melo M , Cunha N , Rascao M J , Neves A , Gilde P , Pires J L , Cruz C , Oliveira C , Neto J , Oliveira S , Valido F , Gomes I , Carvalheiro M , Rodrigues F

Background and aims: The value of the revised (2009) UICC/TNM criteria for medullary thyroid cancer (MTC) is not established. We aimed to evaluate its predictive value, analyzing the consequences of the inclusion of T3N0M0 patients previously included in stage III of the 6th edition, in stage II of the 7th.Patients and methods: We retrospectively analysed the clinical records of 85 patients operated for MTC and followed in two tertiary hospitals in the c...