Searchable abstracts of presentations at key conferences in endocrinology

ea0013p16 | Bone | SFEBES2007

Wnt/β-catenin signalling is abrogated in mice with a targeted mutation in the thyroid hormone receptor (TR) β gene and a thyrotoxic skeletal phenotype

O’Shea Patrick J , Davis Sean , Walker Robert L , Meltzer Paul S , Williams Graham R , Cheng Sheue-yann

Thyroid hormone (T3) is an important regulator of skeletal development and bone turnover. Thyrotoxicosis is associated with accelerated growth, advanced bone age and osteoporosis. T3-action in bone is mediated mainly by T3-receptors (TRs). TRβPV mice harbour a dominant-negative mutation in the TRβ gene that impairs negative feedback control of the hypothalamic-pituitary-thyroid axis resulting in elevated thyroid hormone and TSH concentrations. TRβ<sup...