ea0013p16 | Bone | SFEBES2007
OShea Patrick J
, Davis Sean
, Walker Robert L
, Meltzer Paul S
, Williams Graham R
, Cheng Sheue-yann
Thyroid hormone (T3) is an important regulator of skeletal development and bone turnover. Thyrotoxicosis is associated with accelerated growth, advanced bone age and osteoporosis. T3-action in bone is mediated mainly by T3-receptors (TRs). TRβPV mice harbour a dominant-negative mutation in the TRβ gene that impairs negative feedback control of the hypothalamic-pituitary-thyroid axis resulting in elevated thyroid hormone and TSH concentrations. TRβ<sup...