ea0090p337 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023
da Silva Hellen
, Mendonca Duarte Luiza
, De Souza Seixas Michele
, Antunes Rodrigues Jose
, de Paula Francisco
, Elias Lucila
Obesity is associated with peripheral and central low grade inflammation characterized by the increase in pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF). Phosphodiesterase 4 (PDE4) modulates the inflammatory responses and its inhibitor can strongly reduce TNF release and inflammation. Additionally, PDE4 knockout mice were shown to be resistant to diet-induced obesity (DIO). The aim of this study was to investigate the role of central and peripheral effec...