Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep1002 | Hot topics (including COVID-19) | ECE2020

Intact endothelial epoxyeicosatrienoic acids pathway in primary aldosteronism – the route to new treatment strategies?

Fruehbuss Laura , Meng Yao , Sun Jing , Gonzalez Marques Jair , Koletzko Berthold , Mederos Y Schnitzler Michael , Gudermann Thomas , Beuschlein Felix , Ann Williams Tracy , Heinrich Daniel , Adolf Christian , Reincke Martin , Schneider Holger

Rationale: Endothelial dysfunction (ED) is a hallmark of primary aldosteronism and paves the way for subsequent atherosclerotic disease. Past research has confirmed that one factor involved in ED is disturbed nitric oxide (NO) signalling. Since defects in NO release alone cannot explain the whole effect, we set out to address the role of endothelial CYP-expoygenase products (epoxyeicosatrienoic acids, EETs) in aldosterone-mediated endothelial dysfunction.<p class="abstext"...