Endocrine Abstracts

Background: Osteoporosis (OP) is underdiagnosed and frequently left untreated. CT derived bone mineral density (BMD) and identification of vertebral compression fracture (VCF) on CT done for another indication are 2 new artificial intelligence (AI) based techniques for opportunistic diagnosis of OP. Our aim was to assess the clinical impact of opportunistic diagnosis of OPMethods: This retrospective study included men and women over age 50, insured by Cl...

Background: When US characteristics and the diameter of a thyroid nodule (TN) justify further evaluation to rule out or to establish the diagnosis of thyroid cancer (TC), fine needle aspiration (FNA) biopsy for cytology (FNAC) is indicated. A major limitation of FNAC is the high rate of indeterminate significance (~30%) results, which require further evaluation. Although recently introduced molecular testing contributed to the ability to differentiate benign from malignant TNs...

Introduction: Fragility fractures are increasingly recognized as a complication of diabetes mellitus (DM). Disease duration, poor glycemiccontrol, diabetes complication, and glycemic variability may be associated with increased risk.Aim: To investigate the association between glycemic control and hip fracture (HF) risk in a cohort of diabetic patients.Methods: This retrospective cohort study included all patients 50 years and older...

Introduction: Familial hypocalciuric hypercalcemia (FHH) is a rare mostly asymptomatic genetic disorder affecting the calcium sensing receptor (CaSR) and its associated proteins with autosomal dominant inheritance. Mutation in AP2S1 gene is responsible for FHH3.Aim: Expand the phenotype of FHH type 3.Methods: Clinical and biochemical characterization of a patient with de-novo FHH3 mutation.Results: S...

Background: Thyroglobulin, serves as a specific tumor marker following thyroidectomy in differentiated thyroid cancer (DTC) patients. However, its role as DTC predictor in patients with thyroid nodules (TN) is controversial.Aim: We aimed to assess the potential role of preoperative serum thyroglobulin concentration to predict DTC in patients who were operated for thyroid nodular disease.Methods: This retrospective study included pa...

Introduction: Hyperprolactinemia is usually an acquired condition. Typical clinical manifestations include hypogonadism, infertility, and galactorrhea. Rarely, hyperprolactinemia has been attributed to a variant in the prolactin receptor gene (PRLR), presenting as agalactia, without hypogonadism, infertility, or galactorrhea.Aim: In the current study we aimed to delineate the clinical phenotype and the genetic basis of marked hyperprolactinemia ...

Introduction: Fine needle aspiration (FNA) for thyroglobulin (Tg) measurement (FNA-Tg) and for cytology (FNAC) are recommended for the evaluation of cervical lymph nodes (LN) suspected as differentiated thyroid carcinoma (DTC) metastases. LN proven to represent a metastasis of thyroid origin, change the operation plan, both prior to surgery and while encountering suspicious LN during surgery.Aim: To assess the diagnostic accuracy of a novel point-of-care...

Background: Rates of osteoporosis treatment following hip fractures are low. Fracture liaison service (FLS) has been shown to increase medical treatment for osteoporosis and decrease mortality. The aim of our study was to assess the impact of in hospital FLS on mortality and second hip fracture.Methods: This retrospective study included patients over 65 years of age, insured by “Clalit” health service who were admitted to Soroka University Medi...