Endocrine Abstracts

Introduction and aimGraves’ disease which is the most common cause of hyperthyroidism is an autoimmune disease presenting with goitre, orbitopathy and dermopathy. The disease is caused by stimulant type TSH receptor antibodies (TRAB). TSH receptor (TSHR) has been shown in different tissues other than thyroid. Testis is one of the extrathyroidal tissues with TSHR. The aim of this study was to investigate relationship between TRAB and inhibin-B, whic...

Objective: To evaluate the relation of mean platelet volume (MPV) levels with serum paraoxonase-1 activity in diabetic patients with respect to obesity and diabetic complications.Methods: A total of 201 diabetic patients grouped with respect to obesity obese (n=89) and non-obese (n=112) and diabetic complications with (n=50) or without (n=150) microvascular complications and with (n=91) or without (n=...

Introduction-aim: Non-alcoholic fatty liver disease (NAFLD) is a clinical condition of uncertain etiology, in whose pathogenesis several mechanisms are involved and which is defined by fat vacuoles in more than 5% of hepatic histiocytes in the absence of serious alcohol consumption. It is frequently comorbid with obesity and insulin resistance. However, NAFLD is also seen in non-obese individuals. The purpose of this study was to compare insulin resistance and metabolic parame...

Introduction: Both overweight/obesity and central obesity were inversely associated with anemia in the studies. In our study, we aimed to determine the relationship between different haemoglobin (Hb) levels and BMI.Materials and methods: A total of 146 patients (131 (89.1%) female and 15 (10.2%) male) were enrolled in the study. Patients were divided into five groups namely group-1 (Hb ≤7 g/dl), group-2 (7 g/dl<Hb ≤10 g/dl), group-3 (10 g...

LCH is a rare proliferative histiocytic disorder, and it can infiltrate virtually any site in the body. Diabetes incipidus (DI) is the most common abnormality when there is involvement of the hypothalamic-pituitary axis (HPA). We have evaluated the anterior pituitary function and their responses to treatment in 9 patients (5M/4F; range 19–60 years) with proven LCH and DI. Endocrine evaluations consisted of clinical history, basal (GH, IGF-1, fT4, TSH, PRL, cortisol, LH, F...

Introduction: Primary pituitary sarcoma causally unrelated to radiotherapy, but an increased risk of second brain tumors continues beyond 20 and 30 year after treatment.We report an acromegalic patient with intrasellar giant adenoma invased suprasellar and nasal cavity during follow-up after radiotherapy.Case: A 39-year-old woman had transsphenoidal and transcranial operation in 2002 and 2003 respectively. She had also conventional...

Introduction: We have reported a case of breast carcinoma complicated by diabetes insipidus due to pituitary metastasis.Case: A 47 years old woman had been referred our clinic with the symptoms of polyuria, polydypsia, weight loss, and fatigue. She had a diagnosis of breast carcinoma for six years, underwent radically mastectomy, chemotherapy and radiotherapy, subsequently. Vertebral metastasis was detected and local radiotherapy was performed six months...

Purpose: Tumor-associated protein called as anterior gradient 2 (AGR2), which is defined particularly in breast and lung carcinomas, is involved in a variety of cellular functions such as cell migration, differentiation and proliferation. Since the role of AGR2 expression in pituitary adenomas is not well known yet, it was aimed to compare AGR2 expression in normal pituitary tissue and pituitary adenoma specimens in the study.Material and Method: We incl...

Idiopathic granulomatoushypophysitis is a rare inflammatory disease which is characterized by inflammation and cellular infiltration of the pituitary gland. The infiltration may cause pituitary insufficiency, compression symptoms due to mass effect and diabetes insipidus. We report the case of a 33-year-old female patient who presenting with weakness, fatigue, amenorrhea and worsening of headaches about 3 months. The patient did not have blurring vision and polyuria-polydipsia...

Preoperative preparation of the hyperthyroid patient for thyroidectomy is imperative to avoid perioperative complications due to severe thyrotoxicosis. 24-years old woman was admitted at our clinic for uncontrolled Graves’ disease. In our case, agranulocytosis introduced by propylthiouracil. Therefore, surgery was the only chance of an effective therapy. In cases when the patient is unresponsive to medical therapy or when such therapy is contraindicated, therapeutic plasm...