Searchable abstracts of presentations at key conferences in endocrinology

ea0063p694 | Pituitary and Neuroendocrinology 2 | ECE2019

New markers of systemic inflammation and oxidative macromolecular damage in partial and total Adult Growth Hormone Deficiency

Bruno Carmine , Vergani Edoardo , Brunetti Alessandro , Guidi Francesco , Angelini Flavia , Meucci Elisabetta , Silvestrini Andrea , Basile Umberto , Mancini Antonio

It is known that adult growth hormone deficiency (GHD) is associated with oxidative stress (OS): both GH and IGF-1 exert antioxidant functions. OS is in turn related to systemic inflammation and cardiovascular/oncological risk. Discordant data concerning GH effects on antioxidants are reported. Moreover, no data are available in partial GHD, which can induce cardiovascular alterations. To evaluate oxidative damage on macromolecules and systemic inflammation, 80 patients, studi...

ea0037ep1071 | Thyroid (non-cancer) | ECE2015

Could thyroid replacement therapy not be enough to reduce oxidative stress in hypothyroid patients with Down' syndrome? A cohort study

Villani Emanuele Rocco , Onder Graziano , Carfi Angelo , Pagano Francesco , Raimondo Sebastiano , Di Segni Chantal , Silvestrini Andrea , Meucci Elisabetta , Mancini Antonio

Hypothyroidism and autoimmune thyroiditis are common in patients with Down’ syndrome (DS), leading to common prescription of thyroid replacement therapy. On the other hand, thyroid function is involved in oxidative stress (OS) mechanisms. DS is a well-known high OS condition because several genes involved in OS mechanisms map on chromosome 21 and coenzyme Q10, lipophilic antioxidant, could be more correlated with hypothyroidism than TSH in DS people. To investigate relati...

ea0032p87 | Bone and Osteoporosis | ECE2013

Oxidative stress in middle age males with osteoporosis: correlation of hormonal pattern and plasma total antioxidant capacity

Raimondo Sebastiano , Tamburrelli Francesco Ciro , Di Segni Chantal , Persano Mariasara , Festa Roberto , Silvestrini Andrea , Meucci Elisabetta , Pontecorvi Alfredo , Mancini Antonio

Male idiopathic osteoporosis is an underestimated disease, despite its clinical and social importance. The biochemical mechanisms are still poorly understood even if the interaction between genetic factors and hormone environment (especially gonadal steroids and GH) plays a undoubtful role. In previous studies we demonstrated low plasma total antioxidant capacity (TAC) in hypogonadal patients. The aim of this study was to investigate oxidative stress as risk factor for bone fr...

ea0056gp66 | Cardiovascular | ECE2018

Evaluation of irisin levels in chronic heart failure with preserved or reduced ejection fraction

Mancini Antonio , Silvestrini Andrea , Bruno Carmine , Vergani Edoardo , Brunetti Alessandro , Favuzzi Angela Maria Rita , Guidi Francesco , Meucci Elisabetta , Mordente Alvaro

Background: The recently discovered myokin Irisin, a peptide originated by a proteolytic cleavage of the transmembrane protein fibronectin type III domain containing 5 (FNDC5) whose expression is induced by exercise and/or by increasing peroxisome proliferator-activated receptor (PPAR)-γ co-activator 1α (PGC-1α), has been considered a prognostic factor in Chronic Ischemic Cardiomyopathy and Acute Heart Failure. Nevertheless, no data are available on Irisin level...

ea0070aep15 | Adrenal and Cardiovascular Endocrinology | ECE2020

Multiple hormonal deficiency in heart failure with preserved ejection fraction: Prevalence and role in modulation of antioxidant levels and myocardial dysfunction indexes

Bruno Carmine , Vergani Edoardo , Calarco Rodolfo , Anna Nicolazzi Maria , Maria Rita Favuzzi Angela , d’Abate Claudia , Silvestrini Andrea , Meucci Elisabetta , Mordente Alvaro , Mancini Antonio

In heart failure with reduced ejection fraction, catabolic mechanisms have a strong negative impact on mortality and morbidity. The relationship between anabolic hormonal deficiency and heart failure with preserved ejection fraction (HFpEF) has still been poorly investigated. On the other hand, oxidative stress is recognized as a player in the pathogenesis of HFpEF. Therefore, we performed a cohort study in HFpEF in order to: 1) define the multi-hormonal deficiency prevalence ...

ea0016p630 | Reproduction | ECE2008

Systemic and seminal antioxidant systems in infertile men with chronic alcohol abuse

Mancini Antonio , Festa Roberto , Grande Giuseppe , Di Donna Vincenzo , Di Nicola Marco , Janiri Luigi , Tiano Luca , Paolo Littarru Gian , Pontecorvi Alfredo , Meucci Elisabetta

Oxidative stress is associated with chronic alcoholic abuse; it is also a mechanism involved in male infertility. To further investigate the relationships between these two conditions, we studied 6 patients with diagnosis of Alcohol Dependence (DSM-IV) during post-detoxification phase, who consulted our centre for infertility. We evaluated seminal parameters, hormone pattern, Total Antioxidant Capacity (TAC) and the lipophilic antioxidant Coenzyme Q10 (CoQ10), both in blood an...

ea0016p752 | Thyroid | ECE2008

Low-T3 syndrome in chronic obstructive pulmonary disease and heart surgery patients: evaluation of plasma antioxidant systems

Mancini Antonio , Corbo Giuseppe Maria , Scapigliati Andrea , Leone Erika , Conti Mirella , Littarru Gian Paolo , Meucci Elisabetta , De Marinis Laura , Pontecorvi Alfredo

Previously, we demonstrated an inverse correlation between CoenzymeQ10 (CoQ10) and thyroid hormones, suggesting its usefulness as index of thyroid hormone tissue effect. A low-T3 syndrome, observed in chronic diseases, is considered an adaptive mechanism and its treatment is still debated. To evaluate the metabolic status of these patients and antioxidant vs energetic role of CoQ10, we studied 32 patients, with chronic obstructive pulmonary disease (COPD), comparing respirator...