Searchable abstracts of presentations at key conferences in endocrinology

ea0059n2.2 | Nurse Session 2: Adrenal crisis & steroid education; raising the safety bar | SFEBES2018

National Education Programme for Patients with Chronic Adrenal Insufficiency

Meyer Gesine

Appropriate hydrocortisone adjustment by the patient himself in situations of increased demand, e.g. in gastrointestinal or febrile infections, is indispensable to prevent adrenal crises (AC). Previous studies revealed a lack of knowledge concerning self-management in patients with AI. A comprehensive patient education is one of the key measures to avoid life-threatening AC. In November 2014, a working group of the adrenal section in the German Endocrine Society (DGE) met to d...

ea0063p33 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

Complete remission of a highly aggressive, metastasized, SDHB-related paraganglioma after chemotherapy with CVD and peptide-receptor radiotherapy

Meyer Gesine , Koch Christine , Bojunga Jorg

Case: A 40-year-old woman presented in 04/2015 with pain in the upper abdomen and a history of paroxysmal tachycardia. Plasma normetanephrines were highly elevated. Imaging revealed a large retroperitoneal tumor (15×12×8 cm), which could be completely resected after pre-treatment with urapidil. Histology confirmed diagnosis of a paraganglioma. Genetic diagnostics detected a previously unknown mutation in intron 2 of the SDHB-gene (c.200+5G>C). Six month after ini...

ea0037oc9.4 | Adrenal 2 | ECE2015

More than 2.5-fold increased risk for adrenal crises in patients with Addison's disease and the autoimmune polyglandular syndrome compared with secondary adrenal failure: German health insurance data 2010--2013

Meyer Gesine , Badenhoop Klaus , Linder Roland

Introduction: Adrenal crises are potentially life-threatening complications in patients with adrenal insufficiency (AI). Our objective was to investigate the frequency of adrenal crises in patients with different forms of AI in the Techniker Krankenkasse (TK), one of the largest German Health Insurance providers, covering more than 12% of the German population.Design: The Statutory Health Insurance (SHI) database of the TK was analysed for diagnostic cod...

ea0035p34 | Adrenal cortex | ECE2014

High risk for adrenal crises in patients with autoimmune Addison's disease: health insurance data 2008–2012

Meyer Gesine , Badenhoop Klaus , Linder Roland

Introduction: Adrenal crisis is a potentially life-threatening complication in primary adrenal failure. Our objective was to investigate the frequency of adrenal crises in patients with autoimmune Addison’s disease (AD) in the Techniker Krankenkasse (TK), one of the largest German Health Insurance providers, that covers more than 10% of the German population.Design: The Statutory Health Insurance (SHI) database of the TK was analysed for diagnostic ...

ea0063p432 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

Case report: giant adrenal myelolipoma in CAH – should all patients be screened by ultrasound for adrenal masses?

Mondorf Antonia , Flugel Anna Katharina , Meyer Gesine , Bojunga Jorg

Introduction: Myelolipomas account for 5–15% of all resected adrenal masses and are considered as benign lesions consisting of fat and myeloid tissue. Their pathogenesis is mostly unknown, though altered mesenchymal stem cell function or a sustained respond to increased ACTH stimulation are discussed. Even though these findings are partly inconclusive, an increased incidence of myelolipoma in patients with congenital adrenal hyperplasia (CAH) has been reported, which may ...

ea0049ep5 | Adrenal cortex (to include Cushing's) | ECE2017

Long-term assessment of AddiQoL and patient diaries may identify Addison patients at high risk for adrenal crises

Koch Maike , Badenhoop Klaus , Herrmann Eva , Meyer Gesine

Introduction: Several studies have shown a reduced quality of life (QoL) in patients with Addison’s disease (AD). However, by now there are no data investigating the changes of QoL over a long-term course. Adrenal crises (AC) are frequent and potentially life-threatening complications in patients with AD. Since no reliable laboratory indicator can predict impending crises it is difficult to detect patients at increased risk. The purpose of this study was to test whether t...

ea0041ep339 | Clinical case reports - Thyroid/Others | ECE2016

A rare case of sex reversal during puberty

Meyer Gesine , Sohn Michael , Badenhoop Klaus , Bojunga Jorg

A 34-year-old refugee from Somalia was referred because of a suspected DSD. Due to ambiguous, but predominantly female external genitalia at birth he was raised as a girl, whereas his subjective gender identity has always been male. Puberty led to a significant virilization of the body but only to a very limited virilization of the external genitalia. The patient presented himself with an undoubtedly male-type body composition. External genitalia were now predominantly male wi...

ea0032p27 | Adrenal cortex | ECE2013

Increasing prevalence of Addison’s disease in Germany: health insurance data 2007–2011

Meyer Gesine , Neumann Kathrin , Badenhoop Klaus , Linder Roland

There are no epidemiological data of Addison’s disease in Germany. Since there is no national registry for this rare disease alternative data sources need to be retrieved. The Technikerkrankenkasse (TK) is one of the large German health care insurance providers covering nearly 10% of the population. Documentation of diagnoses by all members with a doctor contact is evaluated by a scientific institute (WINEG). Screening of the database for Addison’s disease was design...

ea0056gp62 | Bone and Osteoporosis | ECE2018

Inflammatory profile in monocytes of patients with Addison’s disease and Vitamin D effects

Kraus Anna , Penna-Martinez Marissa , Meyer Gesine , Badenhoop Klaus

Introduction: Vitamin D (VD) deficiency affects many autoimmune disorders requiring steroid therapy. In contrast to glucocorticoid immune suppressive doses for autoimmune diseases, patients with Addison’s disease (AD) require physiological replacement. There is growing evidence of a cross-talk between glucocorticoids (GC) and VD. However, VD’s interaction with the GC pathway remains poorly understood.Methods: To explore this issue, CD14+</...

ea0035p523 | Endocrine tumours and neoplasia | ECE2014

A rare case of an androgen-producing stromal luteoma of the ovary in a postmenopausal woman, diagnosed by means of selective venous blood sampling

Bogdanou Dimitra , Meyer Gesine , Stucker Anja-Undine , Hansmann Martin-Leo , Thalhammer Axel , Bojunga Jorg

Background: Multiple diagnostic modalities may be needed to establish the source of excessive androgen production in women. The detection of testosterone-producing ovarian tumors by imaging techniques can be difficult because of their in same cases small size and radiological structure.Case report: We describe a 55-year-old postmenopausal woman presenting with progressive severe virilization (Ferriman Gallwey-Score: 23–26), increased hair growth, ma...