Endocrine Abstracts

A 38 female patient with a diagnosis of primary CNS lymphoma was admitted for MATRIX (methotrexate, rituximab, thiopeta, cytarabine) chemotherapy. Prior to chemotherapy and while on steroids she became increasingly polydipsic and polyuric with blood biochemistry demonstrating a sodium of 164 mmol/l. An endocrine review of the patient was requested and a diagnosis of cranial diabetes insipidus was suspected due to the extent of infiltration of the hypothalamus and pituitary sta...

The skeletal dysplasias or genetic skeletal disorders (GSDs) are a heterogeneous group of over 450 conditions associated with varying degrees of disproportionate short stature. The diagnosis of these conditions has relied on a combination of clinical and radiographic assessment. The original classifications of the GSDs was based on x-ray imaging, but Spranger and others predicted that there would be ‘families’ of GSDs with the same underlying molecular basis. The adv...

Despite significant progress, deficiencies of iron and iodine remain major public health problems affecting >30% of the global population. These deficiencies often coexist in populations. Iron deficiency has adverse effects on thyroid metabolism. Iron deficiency impairs thyroid hormone synthesis by reducing activity of heme-dependent thyroid peroxidase. Iron-deficiency anemia blunts, and iron supplementation improves the efficacy of iodine supplementation. Studies have dem...

In vitro diagnostics (IVD) in the European Union is facing a fundamental change with the introduction of a new regulation, the so-called In Vitro Diagnostics Regulation (IVDR). Originally, the IVDR was scheduled to enter into force in May 2022, however, in January 2022, the EU legislator made a differentiated partial postponement of the application of important parts of the IVDR. The major innovation and achievement of the IVDR is that most commercially manufactured IVD produc...

This talk will focus on contraceptive options for patients with polycystic ovary syndrome (PCOS). Key considerations for clinicians will be explored, including the choice of appropriate formulations for cycle regulation, control of symptoms of androgen excess and suppression of dysfunctional menstrual bleeding. Other issues covered during this session will include contraceptive options in patients with obesity or at high risk of complications such as venous thromboembolism, as...

A 36-year-old female was referred to Endocrinology by her GP in August 2019 with polycythaemia, obesity, hypertension, type 2 diabetes, asthma, right shoulder and bilateral ankle pain [on 6-monthly steroid injections], easy bruising, hirsutism, PCOS and raised testosterone. Haematology had excluded likely causes of polycythaemia [JAK 2 negative]. The GP noted previous review by Endocrinology in another hospital [December 2012] regarding possible PCOS but was lost to follow up ...

Insulin resistance and androgen excess, alongside anovulatory infertility, are the cardinal clinical and biochemical features of polycystic ovary syndrome (PCOS). Circulating androgen burden and metabolic dysfunction in PCOS are closely correlated, but an independent contribution of androgens perseto metabolic and other complications of PCOS remains poorly characterised. My work focuses on delineating the distinct impact of androgens on metabolic function, with a part...

To date, magnetic resonance tomography is generally considered the imaging method of choice for its premium resolution of lesions and surrounding anatomic structures. This is mainly due to the improved soft tissue contrast this method offers. Other advantages are the possibility of direct multiplanar imaging in sagittal, coronal, and axial orientations and the avoidance of ionizing radiation. The goal of all imaging studies in this region is to indicate precisely the location,...

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177Lu-labelled compounds show many advantages for dosimetry assessments due to the attractive physical properties of the isotope which comprise a clearly separated gamma peak at 208 keV and low abundance of photons which permits reliable quantitative imaging after therapy. In addition, the low range of beta particles is advantageous for radiation protection. This talk mainly focuses on dosimetry methodology which includes consideration of the number and time points ...