Searchable abstracts of presentations at key conferences in endocrinology

ea0028p315 | Steroids | SFEBES2012

Suppression of adrenal cortisol metabolism by type 2 11β-hydroxysteroid dehydrogenase enzyme (11βHSD2) in the luteal phase of the ovine oestrous cycle

Tennant Laura , McIlvride Saraid , Abayasekara Dilkush , Michael Anthony

We have previously investigated the ability of glucocorticoids secreted by the adrenal cortex to directly influence gonadal function. In contrast, the primary aim of the present study was to assess whether increased progesterone output from the corpus luteum on day 14 of the ovine oestrous cycle can alter adrenal metabolism (and hence output) of cortisol relative to oestrous cycle day 5. Since cortisol-cortisone inter-conversion by the cloned 11β-hydroxysteroid dehydrogen...

ea0021oc5.2 | Steroids and thyroid | SFEBES2009

De novo cortisol synthesis by primary human keratinocytes

Hannen Rosalind , Michael Anthony , Burrin Jacky , Philpott Micheal

Cortisol-based therapy is still the most potent anti-inflammatory treatment available for skin conditions such as psoriasis and atopic dermatitis. Previous studies have demonstrated the presence of components of the steroidogenic pathway in keratinocytes, though surprisingly none have reported that these cells, which form up to 90% of the epidermis are able to synthesise cortisol1,2. Here, we demonstrate that primary human keratinocytes (PHK) are capable of de no...

ea0028p316 | Steroids | SFEBES2012

Impact of prenatal androgens on glucocorticoid metabolism in an ovine model of PCOS.

McIlvride Saraid , Ellison Alicia , Hogg Kirsten , McNeilly Alan , Duncan Colin , Michael Anthony

Within target cells, cortisol-cortisone inter-conversion is catalysed by both a NADP(H)-dependent, bidirectional type 1 11β-hydroxysteroid dehydrogenase (11βHSD1) enzyme and by a NAD+-dependent, unidirectional type 2 11βHSD (11βHSD2) isoenzyme. Since several published studies have reported altered glucocorticoid metabolism in polycystic ovary syndrome (PCOS), the current study assessed whether prenatal exposure of lambs to testosterone propionate...