Searchable abstracts of presentations at key conferences in endocrinology

ea0016p506 | Obesity | ECE2008

Cholinergic regulation of meal induced ghrelin and PYY release is impaired in obesity

Maier Christina , Riedl Michaela , Vila Greisa , Wolzt Michael , Clodi Martin , Ludvik Bernhard , Luger Anton

Ghrelin and PYY are gastrointestinal peptides involved in appetite regulation. The cholinergic part of the vagal nerve participate in the regulation of glucose and insulin levels. We aimed to examine the effects of the cholinergic antagonist atropine on ghrelin, PYY, glucose and insulin under basal conditions and after meal ingestion in lean and obese subjects. Eight lean and eight obese subjects received in a randomized, double-blind, placebo controlled crossover study design...

ea0014p243 | (1) | ECE2007

Fasting and postprandial plasma obestatin levels are reduced in obesity

Maier Christina , Haider Dominik , Vila Greisa , Riedl Michaela , Luger Anton , Wolzt Michael

Obestatin has recently been identified as a peptide derived from pre-proghrelin that opposes ghrelin effects on appetite and body weight in rodents. We studied the effect of food intake on both these hormones in obese and lean subjects and recorded in parallel the subjective sensations of satiety and hunger. Eight obese (two males and six females, BMI=31–52 kg/m2) and eight age- and sex-matched lean subjects (BMI=19–23 kg/m2) were randomized to ...