ea0056p828 | Pituitary - Clinical | ECE2018
Cappellani Daniele
, Michela Gabelloni
, Cosottini Mirco
, Urbani Claudio
, Marconcini Giulia
, Manetti Luca
, Marcocci Claudio
, Bogazzi Fausto
, Lupi Isabella
Background: Temozolomide is an alkylating chemoterapic agent that ties a methyl to guanine, causing a base-pair mismatch and a DNA damage, resulting in cell death. Due to its lipophilic nature and its ability to cross the blood-brain barrier, this drug was originally used for malignant gliomas and later for aggressive pituitary tumors and carcinomas. Temozolomide is now recommended as first-line chemotherapy by the recently published ESE Clinical Practice Guidelines. Here we p...