Searchable abstracts of presentations at key conferences in endocrinology

ea0049eje1 | The European Journal of Endocrinology Prize Lecture | ECE2017

Hypothalmic AMPK: a golden target against obesity?

Lopez Miguel

AMP-activated protein kinase (AMPK) is a cellular gauge that is activated under conditions of low energy, increasing energy production and reducing energy waste. Centrally, the AMPK pathway is a canonical route regulating energy homeostasis, by integrating peripheral signals, such as hormones and metabolites, with neuronal networks. Current evidence links hypothalamic AMPK with feeding, brown adipose tissue (BAT) thermogenesis and browning of white adipose tissue (WAT), as wel...

ea0035s25.1 | Gonadal hormones and obesity | ECE2014

Gonadal hormones and obesity: estrogens and body weight

Lopez Miguel

The gonadal axis is an important modulator of both energy balance and metabolism. Estradiol administration to either ovariectomized female or male rats leads to inhibition of food intake and decreased body weight. Other studies have suggested the presence of estrous cycle variation in meal size and body weight in rodents, as well as during pregnancy and lactation. Recent data also indicate that estradiol modulates the appetite responses to central and peripheral signals and th...

ea0022s28.2 | Hypothalamic networks and energy homeostasis | ECE2010

Brain lipogenesis and the control of food intake: the lipostatic hypothesis revisited

Lopez Miguel

The ‘classical’ hypothalamic neuropeptide view of feeding regulation has been extensively reviewed and revised during the last few years. Accumulating evidence indicate that pharmacological and genetic modulation of lipogenesis de novo in the hypothalamus, through selective pharmacologic and genetic manipulation of acetyl-CoA carboxylase (ACC), AMP-activated protein kinase (AMPK), carnitine palmitoyltransferase-1 (CPT1), fatty acid synthase (FAS) and malonyl-C...

ea0073aep267 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

p63 induces the fibrosis in NASH

Fondevila Marcos F , Novoa Eva , Uxía Fernández , María J González-Rellán , Lima Natalia , Begoña Porteiro , Juan Cuñarro , Tovar Sulay , Fidalgo Miguel , Martinez-Chantar Maria Luz , Sabio Guadalupe , Marcos Miguel , Lopez Miguel , Dieguez Carlos , Rubén Nogueiras

p53 family controls several metabolic and cellular functions. The p63 member regulates lipid metabolism in hepatocytes and contributes to the development of liver steatosis. Here we show that p63 plays an important role in liver fibrosis. P63 is upregulated in patients with NASH, correlating positively with fibrosis score and collagen 1a1 expression. P63 expression is also increased in different animal models of diet-induced NASH and chemically induced liver fibrosis. Mice wit...

ea0032p726 | Obesity | ECE2013

The lack of Nur77 affects energy and glucose metabolism in females fed on high fat diet

Sieira Sonia Perez , Martinez Gloria , Porteiro Begona , Lopez Miguel , Vidal Anxo , Nogueiras Ruben , Dieguez Carlos

Nur77 is an orphan nuclear receptor included in the NR4A family. This protein has been studied as a transcriptional regulator of glucose metabolism in different tissues. We aimed to investigate the endogenous role of Nur77 on energy and metabolic homeostasis. For this purpose, we used male and female Nur77-deficient mice and their wild-type littermates. We challenged them to standard diet and high fat diet, and analyzed different parameters involved in energy balance (food int...

ea0037oc7.2 | Neuroendocrinology and pituitary-basic | ECE2015

KLF4 in hypothalamus regulates leptin homeostatic effects through AgRP

Sanchez-Rebordelo Estrella , Imbernon Monica , Gallego Rosalia , Gandara Marina , Lear Pamela , Lopez Miguel , Dieguez Carlos , Nogueiras Ruben

Introduction: Krüpel-like factor 4 (KLF4) is a zinc-finger-type transcription factor expressed in a range of tissues that plays multiple functions. KLF4 is expressed in neural stem cells and is critical to neuronal differentiation. Recent evidence suggests that KLF4 also plays an important role in the central regulation of energy balance. In vitro studies show that KLF4 is a transcriptional regulator of agouti–related protein (AgRP), essential to the hyperph...

ea0070aep1058 | Hot topics (including COVID-19) | ECE2020

Changes in metabolic control and body composition with Semaglutide sc in patients with type 2 diabetes mellitus

Redondo Enrique , Serrano Mª Carmen , Leon Sara , Andreo Mª Carmen , Sebastian Luisa , Quesada Miguel , Lopez-Ibarra Pablo

Objectives: aGLP1 have been positioned as an effective and safe treatment in patients with Type 2 Diabetes Mellitus (DM2). The objective was to evaluate the changes metabolic and body composition at 6 months after initiation with Semaglutide weekly subcutaneous added to its basic treatment in patients with DM2.Material and Methods: Prospective observational study. Treatment was started in 42 patients with DM2, with weekly subcutaneous Semaglutide with a ...

ea0032p364 | Diabetes | ECE2013

Heterozygous deficiency of endoglin decreases insulin and hepatic triglyceride levels during high fat diet

Beiroa Daniel , Amparo Romero-Pico , Carmen Langa , Carmelo Bernabeu , Miguel Lopez , Lopez-Novoa Jose M , Ruben Nogueiras , Carlos Dieguez

Introduction: Endoglin is a transmembrane auxiliary receptor for transforming growth factor-β (TGF-β) that is predominantly expressed on proliferating endothelial cells. It plays a wide range of physiological roles but its importance on energy balance or insulin sensitivity has been unexplored.Material and methods: Heterozygous deficient mice (HZ) were fed standard chow or high fat diet during 16 weeks. Blood glucose levels were measured after ...

ea0032p753 | Obesity | ECE2013

Chronic central administration of amylin decreases fat mass but does not modify body weight

Touceda David Gonzalez , Pico Amparo Romero , Piedra Monica Imbernon , Couto Begona Porteiro , Tarrio Daniel Beiroa , Lopez Miguel , Nogueiras Ruben , Dieguez Carlos

Aims (objectives): Energy intake and expenditure are regulated by different signals. One of the molecules implicated is islet amyloid polypeptide (IAPP or amylin), one of the major secretory products of β-cells of the pancreatic islets of Langerhans. It is a peptide that inhibits insulin and glucagon secretion, and can also act through the brain decreasing food intake and inhibiting gastric emptying. In this study, we investigated the potential effects of the chronic cent...

ea0056gp156 | Obesity | ECE2018

Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis

Rellan Maria Jesus Gonzalez , Couto Begona Porteiro , Fondevila Marcos Fernandez , Buque Xabier , Fernandez Uxia , Mora Alfonso , Beiroa Daniel , Lopez Miguel , Sabioc Guadalupe , Dieguez Carlos , Aspichueta Patricia , Nogueiras Ruben

Introduction: p53 is a transcription factor involved in many biological functions such as stress, ageing, and metabolism. Although there is a large body of evidence showing that p53 promotes fatty acid catabolism while it inhibits anabolism through the regulation of gene expression, the possible contribution of p53 to the pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains to be elucidated. Also, the anthracycline doxorubicin is an important chemotherapeutic agent...