Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1021 | Pituitary - Clinical | ECE2017

Thyrotropin secreting microadenoma – case report of a patient with goiter

Vale Sonia do , Martins Ana Filipa , Lopez-Presa Dolores , Costa Cristiana , Miguens Jose

Introduction: The prevalence of pituitary thyrotropin secreting tumors (TSH-omas) is 1-2 cases per million inhabitants, most of them being macroadenomas. The differential diagnosis may be challenging, especially for microadenomas.Case Report: A 50-year-old male was observed at the endocrinology department with multinodular goiter. He noticed progressive neck enlargement over the previous months but denied other complaints. There was no family history of ...

ea0049ep896 | Neuroendocrinology | ECE2017

Bilateral inferior petrosal sinus sampling and the outcome of transsphenoidal surgery in patients with Cushing’s disease: experience of a Tertiary Portuguese Hospital

Gomes Ana Coelho , Neto Lia Lucas , Tortosa Francisco , Carvalho Maria Raquel , Barreiros Eduardo , Barreiros Luis , Miguens Jose , Bugalho Maria Joao

Introduction: Bilateral inferior petrosal sinus sampling (BIPSS) is the gold-standard for the differential diagnosis of ACTH-dependent Cushing Syndrome when the pituitary adenoma on MRI is doubtful or absent. This study aimed to analyze whether BIPSS can influence the outcome in patients with Cushing disease (CD).Methods: Retrospective, descriptive study. Forty-two patients with CD submitted to transsphenoidal surgery (TS) between 2005 and 2016 were divi...

ea0049ep974 | Pituitary - Clinical | ECE2017

Cushing’s disease: is there a Continuum from corticotroph hyperplasia to adenoma?

Gomes Ana Coelho , Neto Lia Lucas , Tortosa Francisco , Carvalho Maria Raquel , Barreiros Eduardo , Barreiros Luis , Miguens Jose , Bugalho Maria Joao

Introduction: Successful long-term management of patients with CushingÂ’s disease (CD) remains a challenge. Few studies have analyzed the long-term recurrence rates of CD after transsphenoidal surgery (TS).Objectives: 1) to compare the outcome of patients with and without postoperative criteria for cure; 2) to compare the outcome of patients with and without a histological diagnosis of adenoma.Methods: Retrospective, descriptiv...

ea0049ep897 | Neuroendocrinology | ECE2017

The prevalence of colorectal cancer and colon polyps in acromegaly: thirty years’ experience of a tertiary referral center

Gomes Vania , Barreiros Luis , Barreiros Eduardo , Ferreira Florbela , Gomes Ana , Martins Ana Filipa , Osorio Ana Sofia , Wessling Ana , Silvestre Catarina , Reis Dinis , Nobre Ema , Carvalho Maria Raquel , Mascarenhas Mario , Vale Sonia do , Miguens Jose , Bugalho Maria Joao

Introduction: Several studies suggest a higher risk of colorectal cancer (CRC) and colon polyps (CP) in acromegaly, however there is still controversy regarding associated factors (AF) able to contribute for its development. Data on the prevalence of CRC and CP in Portuguese patients with acromegaly are limited.Objectives: To assess the prevalence of CRC and CP in acromegalic patients and compare to the normal Portuguese population. To determine the rele...

ea0049ep898 | Neuroendocrinology | ECE2017

Acromegaly and malignant neoplasms

Gomes Vania , Barreiros Eduardo , Barreiros Luis , Ferreira Florbela , Gomes Ana , Martins Ana Filipa , Osorio Ana Sofia , Wessling Ana , Silvestre Catarina , Reis Dinis , Nobre Ema , Carvalho Maria Raquel , Mascarenhas Mario , do Vale Sonia , Miguens Jose , Bugalho Maria Joao

Introduction: Acromegaly is a rare disease resulting from pathological oversecretion of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). The clinical spectrum includes cardiovascular and respiratory diseases but also increased risk of benign and malignant neoplasms.Objectives: Evaluate the prevalence of cancer and seek for associated factors in acromegaly.Methods: Retrospective study of 94 patients with acromegaly trea...

ea0049ep1049 | Pituitary - Clinical | ECE2017

Aggressive pituitary tumours: a multicenter study

Palha Ana , Gomes Leonor , Sequeira Duarte Joao , Marques Conceicao , Amaral Claudia , Amado Ana , Borges Fatima , Ribeiro Isabel , Barreiros Eduardo , Barreiros Luis , Miguens Jose , Joao Bugalho Maria , Lages Adriana , Paiva Isabel , Marques Olinda , Almeida Rui , Martins Teresa , Cortez Luisa , Agapito Ana , Fonseca Fernando

Introduction: Pituitary tumours are considered benign, however some exhibit an aggressive behavior. Defining a timely treatment is challenging due to absence of accurate prognostic predictors.Objective: To evaluate radiological and histopathological features of aggressive pituitary tumours.Methods: Multicenter and retrospective study. Criteria for aggressiveness were: invasion to sphenoid and/or cavernous sinus; growth progression ...