Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep588 | Endocrine-related Cancer | ECE2023

An unusual association of a familial MEN1 with renin co secretion form a glucagonoma

Mihai Daniel , Ramona Poalelungi , Badiu Corin

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder consisting in the development of primary hyperparathyroidism (PHPT), pancreatic neuroendocrine tumors, and pituitary adenomas. Occurrence of glucagonoma in MEN1 patients is rare (3%) and metastatic disease is present in 50% to 80% of patients at the time of diagnosis. The association of adrenal nodules/tumors and MEN1 is also rare.Case report: We present the case o...

ea0090ep764 | Pituitary and Neuroendocrinology | ECE2023

A very rare case of familial glucagonoma with renin co-secretion and hypokalemia in MEN1 multiple neoplasia

Poalelungi Ramona , Daniel Mihai , Badiu Corin

Introduction: A glucagonoma is a rare neuroendocrine tumor that originates almost exclusively in the pancreas and probably accounts for 1% of all neuroendocrine tumors. MEN11 is characterized by the development of primary hyperparathyroidism (PHPT), pancreatic neuroendocrine tumors and pituitary adenomas.Methods: We present the case of a 39-year-old female, with history of type 2 diabetes mellitus and hypokalemia2 who presented to t...

ea0041ep16 | Adrenal cortex (to include Cushing's) | ECE2016

Adrenal function recovery after adrenalectomy in Cushing syndrome

Radomir Lidia , Mihai Daniel , Caragheorgheopol Andra , Tomulescu Victor , Badiu Corin

Background: First-line therapy of ACTH-independent Cushing’s Syndrome (CS) is the resection of the underlying tumor in all cases. After surgical cure of CS, most patients develop transient secondary adrenal insufficiency with a variable time of recovery. Adrenal function testing can identify patients who may require glucocorticoid replacement.Methods: We reviewed 61 patients diagnosed with ACTH-independent CS excluding 6 with adrenocortical carcinom...

ea0037ep1129 | Endocrine tumours | ECE2015

Extremes in hyperparathyroidism: management of parathyroid carcinoma

Radomir Lidia , Mihai Daniel , Jercalau Simona , Badiu Corin

Background: Parathyroid carcinoma (PC) is a rare cause of primary hyperparathyroidism (PHPT), accounting for <1%, with an equal gender distribution and an average age of diagnosis in the fifth decade of life. The diagnosis of PHPT is based on the laboratory finding of high levels of immunoreactive PTH in the presence of severe hypercalcaemia. The only potentially curative treatment for PC is surgery. Early surgery is the most important factor for optimal outcome.<p cla...

ea0073aep54 | Adrenal and Cardiovascular Endocrinology | ECE2021

Adrenal function recovery after successful surgery for Cushing

Marin Alexandra , Mihai Daniel , Caragheorgheopol Andra , Badiu Corin

BackgroundCushing syndrome (CS) is caused by prolonged exposure to elevated cortisol levels and it’s classified as either ACTH-dependent or ACTH independent CS. The most common form of endogenous ACTH CS is Cushing disease (CD); ACTH-independent CS is caused by various adrenal abnormalities. First-line therapy in CS is the resection of the underlying tumor in all cases. After surgical cure of CS, most patients develop transient secondary adrenal ins...

ea0049ep1395 | Thyroid (non-cancer) | ECE2017

Stimulated calcitonin levels as a predictor of medullary thyroid cancer

Alexandra Gheorghiu Cristina , Corneci Cristina , Jercalau Simona , Dobrescu Ruxandra , Mihai Daniel , Badiu Corin

Abstract: Medullary thyroid cancer (MTC) is a highly aggressive neuroendocrine tumour originating in the thyroid parafollicular cells. Calcitonin measurement and RET gene ascertainment have been used as markers for early diagnosis of MTC. Since pentagastrin is not available, calcium stimulation test helps to preclude ‘gray zone’ values of basal calcitonin, diagnose minimal residual disease and help the early diagnosis of C cell hyperplasia.Aim:...

ea0070ep501 | Thyroid | ECE2020

Early diagnosis of acromegaly in chronic thyroiditis-case report

Stancu Ana-Maria , Gabriela Marin Alexandra , Beatrice Preda-Ivascu Monalisa , Mihai Daniel , Stancu Cristina , Badiu Corin

Introduction: Acromegaly is characterized by a pituitary adenoma with excess secretion of GH and IGF-1 hormones. More than 90% of the cases are diagnosed as macroadenomas, after 5 to 10 years of clinical manifestation.Case report: We present the case of a 49 years old man with minor thalassemia, hospitalized in endocrinology department for a routine check of chronic autoimmune thyroiditis. A careful anamnesis showed that in the last year the patient was ...