Searchable abstracts of presentations at key conferences in endocrinology

ea0021p38 | Clinical practice/governance and case reports | SFEBES2009

A case of microprolactinoma in a young man presenting as obesity despite regular heavy exercise

Bradley Sarah , Piya Milan , Taheri Shahrad

Introduction: Hyperprolactinaemia may be associated with weight gain and obesity, suggesting that prolactin may modulate body composition and weight. Treatment that normalises prolactin levels using dopamine agonists frequently leads to weight loss and provides further evidence for the association.Case: A 28-year-old South Asian male with a body mass index of 27.2 kg/m2 was referred to a weight management clinic with a five year history of wei...

ea0021p74 | Clinical practice/governance and case reports | SFEBES2009

A case of connective tissue disease complicated by multiple metabolic disorders

Piya Milan , Tahrani Abd , Dyer Philip , Shakher Jayadave , Jones Alan

A 24-year-old Pakistani woman presented one day after returning from a 6-week holiday in Pakistan with a 3-day history of generalised weakness, difficulty in walking and left flank pain. She was known to have mixed connective tissue disease (MCTD). Clinically she was pyrexial and had generalised muscular weakness (power 3/5), and hypotonia. Biochemically, she was found to have hypokalaemia (1.8 mmol/l), raised serum urea (8.1 mmol/l), and creatinine (160 ╬╝mol/l), high ESR...

ea0086p54 | Metabolism, Obesity and Diabetes | SFEBES2022

Metabolic Endotoxemia impacts mitochondrial function and adipocyte browning in a depot specific manner in Human abdominal adipose tissue

Murphy Alice , Omran Farah , Piya Milan , Christian Mark , McTernan Philip

Introduction: Central obesity is a significant risk factor for type 2 diabetes mellitus (T2DM), with omental adipose tissue (AT) particularly involved in such risk. Additionally, obesity can cause low-level gut-derived endotoxemia, which may drive metabolic dysfunction in AT through mitochondrial damage and reduced BRITE (brown-in-white) adipocytes. Bariatric surgery reduces obesity and may prevent such dysfunction. This study investigated whether endotoxin: 1) impairs mitocho...

ea0031p179 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

FGF21 action on human adipose tissue compromised by reduced βKlotho and FGFR1 expression in type 2 diabetes mellitus

Piya Milan K , Harte Alison L , Chittari Madhu V , Tripathi Gyanendra , Kumar Sudhesh , McTernan Philip G

Background/objectives: Fibroblast growth factor 21 (FGF21) is a potent hormone known to reduce glycaemia and improve insulin resistance with anti-obesity effects. Although mainly secreted in the liver, adipose tissue is considered an important target for its function. Whilst FGF21 has been shown to be expressed in murine adipose tissue, studies in human adipose tissue are lacking. Therefore our aim was to examine the expression of FGF21, FGF21 receptor-1 (FGFR1), ╬▓Klotho ...

ea0028p213 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

Chronic or intermittent exposure to Oleic acid (MUFA) induces a greater NFκB activated inflammatory response than Eicosapentaenoic acid (PUFA) in differentiated human adipocytes

Piya Milan , Harte Alison , McGee Kirsty , Reddy Narendra , Tripathi Gyanendra , McTernan Philip , Kumar Sudhesh

Replacement with mono-unsaturated fatty acids (MUFA) or poly-unsaturated fatty acids (PUFA) reduces inflammation in the pre-diabetic subjects but the benefits are unclear in subjects with type 2 diabetes mellitus (T2DM). Our aim was to investigate whether saturated fatty acids (SFA), MUFA and PUFA produce a similar adipocyte inflammatory response, which may explain the rationale for maintained systemic inflammation noted in subjects with T2DM. The differentiated human preadipo...

ea0014p348 | (1) | ECE2007

Removal of tick box for TFT in pathology request forms reduces TFT performed during acute medical admission

Piya Milan , Belbase Biparna , Thapa Meenakshi , Koppada Anu , Myers Martin , Baxter Susan , Rajbhandari Satyan

Joint UK guideline (2006) recommends that routine testing of thyroid function (TFT) in patients admitted acutely to hospital is not warranted unless specific clinical indications exist. Despite this, TFT is frequently requested during acute medical admission. In our previous audit in 2002, during a 1 month period from 18th September, 458 subjects were admitted to medical assessment unit (MAU) and 183 (40%) were offered TFT. 39 (29%) results were beyond the laboratory reference...

ea0013p296 | Thyroid | SFEBES2007

Removal of tick box for TFT in pathology request forms reduces TFT performed during acute medical admission

Piya Milan , Belbase Biparna , Karki-Thapa Meenakshi , Baxter Susan , Myers M , Koppada A , Rajbhandari Satyan Man

Joint UK guideline (2006) recommends that routine testing of thyroid function (TFT) in patients admitted acutely to hospital is not warranted unless specific clinical indications exist. Despite this, TFT is frequently requested during acute medical admission. In our previous audit in 2002, during a 1 month period from 18th September, 458 subjects were admitted to medical assessment unit (MAU) and 183 (40%) were offered TFT. 39 (29%) results were beyond the laboratory reference...

ea0044p179 | Obesity and Metabolism | SFEBES2016

Metabolic endotoxaemia impairs mitochondrial respiration and insulin sensitivity in human adipocytes

de la Escalera Lucia Martinez , Jackisch Laura , Murphy Alice , Piya Milan , Kumar Sudhesh , Tripathi Gyanendra , McTernan Philip G

Background: Metabolic endotoxaemia (raised bacterial endotoxin in serum after high-fat feeding) has been shown to reduce insulin sensitivity in humans through systemic inflammation and oxidative stress. Mitochondria represent the main source of cellular reactive oxygen species and mutations in mitochondrial DNA often result in a diabetic phenotype. However, the direct cellular impact of endotoxin on mitochondrial respiration and DNA integrity, particularly within the context o...

ea0034p226 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014

Meal size and frequency influences metabolic endotoxaemia and inflammatory risk but has no effect on diet induced thermogenesis in either lean or obese subjects

Piya Milan , Reddy Narendra , Campbell Alison , Hattersley John , Halder Louise , Tripathi Gyanendra , Tahrani Abd , Barber Thomas , Kumar Sudhesh , McTernan Philip

Background: Small frequent meals are often recommended for weight loss, with supporting evidence often provided from studies in diabetes. Dietary meal content is also relevant, as high fat meals cause systemic inflammation via gut derived bacteria, endotoxin. As such, repeated meals may exacerbate this. In contrast, dietary induced thermogenesis, related to meal size, may reduce with small frequent meals.Aim: Therefore, the aim of this study was to compa...

ea0031p77 | Clinical practice/governance and case reports | SFEBES2013

A case of dry beriberi following bariatric surgery

Verran Alice , Watkins John , Reddy Narendra , Barber Tom , Piya Milan , Randeva Harpal , Kumar Sudhesh , Aftab Saboor , Sankar Sailesh

Introduction: Over 9000 bariatric surgeries are conducted annually in the UK and post-operative micronutrient deficiency is common. We report a case of dry beriberi secondary to thiamine deficiency following Roux-en-Y bypass surgery.Case presentationA 45-year-old Caucasian obese lady (155 kg, BMI 57) presented with progressive proximal limb weakness, upper and lower limb paraesthesia, ataxia and athetoid tremors 18 months following...