Searchable abstracts of presentations at key conferences in endocrinology

ea0022p542 | Male reproduction | ECE2010

Initial characterization of the human seminal plasma proteome in a fertile normogonadic man by top-down strategy

Milardi Domenico , Vincenzoni Federica , Grande Giuseppe , Antonella Giampietro , Pontecorvi Alfredo , Castagnola Massimo , De Marinis Laura , Marana Riccardo

Human seminal plasma contains a large array of proteins required for the normal physiology of spermatozoa and fertilization. To provide informations about the physiological mechanisms of male fertility we performed proteomic studies on human seminal plasma by a top-down approach. A semen sample was collected in a fertile normospermic man (sperm concentration 60×106 per ml; progressive motility 58%; normal morphology 45%). Hormonal blood assay was performed: tes...

ea0014p602 | (1) | ECE2007

Endocrine and neuro-ophtalmologic correlates of primary empty sella

Bianchi Antonio , Gregori Bruno , Sacco Eugenia , Giampietro Antonella , Milardi Domenico , Fusco Alessandra , Accornero Neri , Pontecorvi Alfredo , De Marinis Laura

Background: Primary empty sella (ES) can be asymptomatic or associated with endocrine and neurological alterations, such as visual defects. Studies in a large number of patients is still lacking.Objective: To study visual deficit in ES and its relationship with hormonal status.Material and Methods: We recorded visual evoked potentials (VEP) by white/black, red/black, blue/black patterns. Isoluminance between red and blue checks all...

ea0035p658 | Female reproduction | ECE2014

High resolution mass spectrometry to study hormonal regulation of cervical mucus proteome during the menstrual cycle

Milardi Domenico , Grande Giuseppe , Vincenzoni Federica , Pompa Giuseppina , Astorri Anna Laura , Fruscella Erika , Biscione Antonella , Messana Irene , Pontecorvi Alfredo , De Marinis Laura , Castagnola Massimo , Marana Riccardo

The chemical composition of the cervical mucus (CM), its physical characteristics and the volume secreted show cyclical changes during the menstrual cycle.Clinical proteomics has recently developed new technologies and bioinformatics useful in identifying molecular markers of physiology and pathology. The development of novel mass spectrometers, like the LTQ-Orbitrap, considerably contributed to increase the quantity of acquired data. Aim of the present ...

ea0035p937 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

IGF1 response to rhGH in adult GHD: role of GH receptor (GHR) isoforms

Bianchi Antonio , Tartaglione Linda , Giampietro Antonella , Milardi Domenico , Angelini Flavia , Mormando Marilda , Lugli Francesca , Piacentini Serena , Grande Giuseppe , Iacovazzo Donato , Chiloiro Sabrina , Pontecorvi Alfredo , Marinis Laura De

The IGF1 response to recombinant human growth hormone (rhGH) showed some individual variability and the responsible factors for this behavior remain unknown. Some studies have emphasized the possible role of isoforms of the GH receptor (GHR), showing conflicting results.Therefore, we investigated the possible influence of the isoforms of the GHR to the diagnosis of GHD and in determining adult hormone replacement therapy responsiveness.<p class="abst...

ea0032p532 | Endocrine tumours and neoplasia | ECE2013

Pituitary transforming gene 1 (PTTG1) expression in seminoma

Milardi Domenico , Grande Giuseppe , Pierconti Francesco , Martini Maurizio , Cenci Tonia , Gulino Gaetano , Schinzari Giovanni , Larocca Luigi Maria , Rindi Guido , Pontecorvi Alfredo , De Marinis Laura

Pituitary transforming gene 1 (PTTG1) is a mammalian securing involved in mitosis to ensure chromosomal stability. PTTG1 is overexpressed in a variety of tumors. It can directly and indirectly induce expression of genes that are involved in regulating tumorigenesis and cancer development (c-Myc, bFGF, VEGF and MMP2).We evaluated PTTG1-expression by immunohistochemistry on formalin-fixed and paraffin-embedded specimen testicular tissues from 53 male patie...

ea0056gp128 | Female Reproduction | ECE2018

Low-dose SKA Progesterone and Interleukin-10 modulate the inflammatory pathway in endometriotic cell lines

Mancini Francesca , Milardi Domenico , Carfagna Piero , Grande Giuseppe , Miranda Vincenzo , De Cicco Nardone Alessandra , Ricciardi Domenico , Pontecorvi Alfredo , Marana Riccardo , De Cicco Nardone Fiorenzo

Endometriosis is a chronic gynecological inflammatory disease characterized by the presence of functional endometrial glands and stroma outside of the uterine cavity. It affects 7–10% of women of reproductive age, up to 50% of women with infertility and up to 60% of women with dysmenorrhea. The aim of this pre-clinical study was evaluate the efficacy of low-dose SKA Progesterone (GUNA) and low-dose SKA IL-10 (GUNA) in the modulation of the inflammatory response in endomet...

ea0056p751 | Neuroendocrinology | ECE2018

Efficacy and safety of a combinated pasireotide lar, pegvisomant and cabergoline treatment in four cases of aggressive somatotrophinomas

Bima Chiara , Chiloiro Sabrina , Giampietro Antonella , Bianchi Antonio , Piacentini Serena , Milardi Domenico , Tartaglione Tommaso , Lauretti Liverana , Anile Carmelo , Pontecorvi Alfredo , Marinis Laura De

Introduction: A significant number of GH-secreting pituitary adenomas show an aggressive behavior, therefore, when uncontrolled acromegaly persists, a pharmaceutical combination may improve biochemical control, with reduction of disease morbidity and mortality. We aimed to describe the clinical features of four patients successfully treated with a pharmacological combination of pasireotide LAR, pegvisomant and cabergoline.Case reports: Acromegaly was dia...

ea0063p681 | Pituitary and Neuroendocrinology 2 | ECE2019

First case of mature teratoma and yolk sac testis tumor associated to inherited MEN-1 syndrome: a case report

Chiloiro Sabrina , Domenico Capolungo Ettore , Schinzari Giovanni , Concolino Paola , Rossi Ernesto , Martini Maurizio , Cocomazzi Alessandra , Grande Giuseppe , Milardi Domenico , Maiorano Brigida , Giampietro Antonella , Rindi Guido , Pontecorvi Alfredo , De Marinis Laura , Bianchi Antonio

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominantly inherited endocrine tumor syndrome characterized by development of cancer in various endocrine organs, particularly in pituitary, parathyroid and pancreas. Moreover, in some cases, also non-endocrine tumors can be diagnosed, developing atypical phenotypes.Case report: We report herein the clinical history of a patient affected by MEN-1 syndrome who developed atypical feat...