Endocrine Abstracts

Multiple endocrine neoplasia (MEN) includes a group of autosomal dominant disorders, associated with the development of a variety of endocrine and non-endocrine manifestations. MEN4 is a rare and the latest reported type in the spectrum of the MEN syndromes. MEN4 was discovered initially in rats (MENX) and later in humans. It is caused by germline and somatic mutations in the cyclin-dependent kinase inhibitor 1B (CDKN1B) tumor suppressor gene, which encodes nuclear protein p27...