Searchable abstracts of presentations at key conferences in endocrinology

ea0077oc1.4 | Reproductive and Neuroendocrinology | SFEBES2021

Intranasal Kisspeptin Administration Stimulates Reproductive Hormone Secretion in Healthy Men

Mills Edouard G , Swedrowska Magda , Thurston Layla , Phylactou Maria , Patel Bijal , Clarke Sophie A , Yang Lisa , Muzi Beatrice , Choudhry Muhammad , Alexander Emma , Abbara Ali , Forbes Ben , Comninos Alexander N , Dhillo Waljit S

Background: Kisspeptin is a critical activator of hypothalamic gonadotrophin-releasing hormone neurons, inducing release of downstream reproductive hormones. Intravenous or subcutaneous kisspeptin administration has been shown to have significant potential to treat reproductive disorders. However, intranasal administration could offer a novel non-invasive delivery route, which would be clinically preferable. We therefore sought to determine the effects of intranasal kisspeptin...

ea0086op3.1 | Reproductive and Neuroendocrinology | SFEBES2022

Kisspeptin enhances penile tumescence and sexual brain processing in men with low sexual desire

Mills Edouard G , Ertl Natalie , Wall Matt B , Thurston Layla , Yang Lisa , Suladze Sofiya , Hunjan Tia , Phylactou Maria , Patel Bijal , Muzi Beatrice , Ettehad Dena , Bassett Paul A , Howard Jonathan , Rabiner Eugenii A , Bech Paul , Abbara Ali , Goldmeier David , Comninos Alexander N , Dhillo Waljit S

Background: Hypoactive Sexual Desire Disorder (HSDD) is associated with a deficiency of sexual desire with marked distress. It affects up to 8% of men, but has no licensed treatments. The reproductive neuropeptide kisspeptin offers a putative therapeutic target owing to its emerging role in modulating reproductive behaviour in animal models and healthy men. However, there are no studies examining its effects in HSDD. To address this, we performed the first clinical study of ki...