Searchable abstracts of presentations at key conferences in endocrinology

ea00100wf1.2 | Workshop F: Disorders of the parathyroid glands, calcium metabolism and bone | SFEEU2024

Challenges in the management of chronic hypoparathyroidism

Mills Edouard G , Ansari Saleem , Behary Preeshila , Cox Jeremy , Comninos Alexander N

Case: We report a 63-year-old woman who was referred to our Endocrine Bone Unit with difficult to control hypoparathyroidism. Sixteen-years previously, she underwent a total thyroidectomy with radioiodine ablation for multifocal papillary thyroid carcinoma with lymph node involvement. However, surgery was complicated by permanent postsurgical hypoparathyroidism, requiring regular calcium supplementation and active vitamin D (Alfacalcidol 1.25 mg). Over the 10-years prior to re...

ea0077oc1.4 | Reproductive and Neuroendocrinology | SFEBES2021

Intranasal Kisspeptin Administration Stimulates Reproductive Hormone Secretion in Healthy Men

Mills Edouard G , Swedrowska Magda , Thurston Layla , Phylactou Maria , Patel Bijal , Clarke Sophie A , Yang Lisa , Muzi Beatrice , Choudhry Muhammad , Alexander Emma , Abbara Ali , Forbes Ben , Comninos Alexander N , Dhillo Waljit S

Background: Kisspeptin is a critical activator of hypothalamic gonadotrophin-releasing hormone neurons, inducing release of downstream reproductive hormones. Intravenous or subcutaneous kisspeptin administration has been shown to have significant potential to treat reproductive disorders. However, intranasal administration could offer a novel non-invasive delivery route, which would be clinically preferable. We therefore sought to determine the effects of intranasal kisspeptin...

ea0090rc10.4 | Rapid Communications 10: Diabetes, Obesity, Metabolism and Nutrition 2 | ECE2023

Kisspeptin does not have detrimental metabolic effects in women

Izzi-Engbeaya Chioma , Choudhury Muhammad , Patel Bijal , Muzi Beatrice , Qayum Ambreen , Mills Edouard G , Ahsan Maheen , Phylactou Maria , Clarke Sophie , Aslett Laura , Comninos Alexander , Abbara Ali , Tan Tricia , Dhillo Waljit

Background: There is emerging evidence that kisspeptin, a hormone with well-established reproductive effects, may also have important metabolic effects. Acute kisspeptin administration enhances insulin secretion under hyperglycaemic conditions in male rodents and men, and kisspeptin receptor agonism improves steatohepatits in male mice in a rodent model of non-alcoholic fatty liver disease. However, the metabolic effects of kisspeptin may exhibit sexual dimorphism as female (b...

ea0086op3.1 | Reproductive and Neuroendocrinology | SFEBES2022

Kisspeptin enhances penile tumescence and sexual brain processing in men with low sexual desire

Mills Edouard G , Ertl Natalie , Wall Matt B , Thurston Layla , Yang Lisa , Suladze Sofiya , Hunjan Tia , Phylactou Maria , Patel Bijal , Muzi Beatrice , Ettehad Dena , Bassett Paul A , Howard Jonathan , Rabiner Eugenii A , Bech Paul , Abbara Ali , Goldmeier David , Comninos Alexander N , Dhillo Waljit S

Background: Hypoactive Sexual Desire Disorder (HSDD) is associated with a deficiency of sexual desire with marked distress. It affects up to 8% of men, but has no licensed treatments. The reproductive neuropeptide kisspeptin offers a putative therapeutic target owing to its emerging role in modulating reproductive behaviour in animal models and healthy men. However, there are no studies examining its effects in HSDD. To address this, we performed the first clinical study of ki...

ea0090oc7.1 | Oral Communications 7: Pituitary and Neuroendocrinology 2 | ECE2023

Investigating intranasal kisspeptin as a novel, effective and preferable route of delivery using human, rodent and pharmaceutical models

Mills Edouard G , Swedrowska Magda , Delli Virginia , Chachlaki Konstantina , Sergio Mauro , Decoster Laurine , Ternier Gaetan , Thurston Layla , Phylactou Maria , Patel Bijal , Yang Lisa , Clarke Sophie , Muzi Beatrice , Alexander Emma , Choudhury Muhammad , Bech Paul , Abbara Ali , Forbes Ben , Giacobini Paolo , Prevot Vincent , Comninos Alexander , Dhillo Waljit

Background: Kisspeptin is a critical activator of hypothalamic GnRH neurons and is essential for reproductive health. Emerging data reveals that kisspeptin-based therapeutics have substantial potential to treat reproductive, psychosexual and bone disorders. However, current delivery is limited to the subcutaneous or intravenous routes, presenting barriers to development. Alternative routes of administration would overcome this and capitalise on the benefits of kisspeptin-based...

ea0099oc1.4 | Oral Communications 1: Reproductive and Developmental Endocrinology | ECE2024

Kisspeptin as a test of hypothalamic function in women presenting with oligo / amenorrhoea

Patel Bijal , Abbara Ali , Yeung Arthur , Phylactou Maria , Tsoutsouki Jovanna , Koysombat Kanyada , Young Megan , Nyunt Sandhi , Qayum Ambreen , Patel Aaran , Zielinska Agata , Omar Yusra , Eng Pei , Mills Edouard G , Hanassab Simon , Webber Lisa , Jayasena Channa , Tan Tricia , Quinton Richard , Clarke Sophie , Comninos Alexander , Dhillo Waljit

Background: Polycystic Ovary Syndrome (PCOS) and Functional Hypothalamic Amenorrhoea (FHA) are the two commonest causes of menstrual disturbance in pre-menopausal women. In practice, differentiating these two common reproductive disorders can be challenging. A fundamental abnormality that underpins both conditions is altered gonadotrophin releasing hormone (GnRH) pulsatility, being increased in PCOS but reduced in FHA. Likewise, congenital (e.g. congenital hypogonadotropic hyp...

ea0099oc9.4 | Oral Communications 9: Pituitary and Neuroendocrinology | Part II | ECE2024

Kisspeptin administration does not alter anxiety or circulating cortisol levels in humans

Mills Edouard G , Thurston Layla , Yang Lisa , Suladze Sofiya , Hunjan Tia , Phylactou Maria , Patel Bijal , Clarke Sophie A. , Shah Amar J. , Izzi-Engbeaya Chioma , Tsoutsouki Jovanna , Bech Paul , Ertl Natalie , Demetriou Lysia , Wall Matthew B. , Goldmeier David , Abbara Ali , Comninos Alexander N. , Dhillo Waljit S.

Background: The neuropeptide kisspeptin is a key endogenous activator of the reproductive system. Due to its crucial role in modulating reproductive and behavioural processes, there has been accelerating interest in targeting kisspeptin-pathways to treat reproductive and psychosexual disorders. However, contradictory pre-clinical data from animal models suggests that kisspeptin can have an anxiolytic, anxiogenic or have no effects on anxiety. Given the rapid development of kis...