Searchable abstracts of presentations at key conferences in endocrinology

ea0014oc2.2 | Bone & calcium metabolism | ECE2007

Role of IGF system on the regulation of osteoblast aromatase activity in vitro

Palermo Claudia , Arvigo Marica , Minuto Francesco

Several studies demonstrated that IGFs stimulate aromatase activity in ovary but no data on bone are available. In the present study the role of IGF system components on aromatase action has been characterized during osteogenic differentiation in a model of rat tibial osteoblasts. At confluence (day 0) cells have been transferred to differentiating medium supplemented with 1% FCS and delta4androstenedion with or without IGF-II 3 nM, IGFBP-2 1 nM and IGFBP-3 1 nM. Cells have be...

ea0020p540 | Growth Factors | ECE2009

IGFBP3 and IGFBP2 negatively and positively modulate IGFs autocrine effect in lung cancer cell lines

Arvigo Marica , Gatto Federico , Ameri Pietro , Ferone Diego , Minuto Francesco

Insulin-like growth factors (IGFs) play an important role in the pathogenesis of several neoplasias and the IGF-binding proteins (IGFBPs) may have a role as autocrine/paracrine factors in regulating the local actions of the IGFs. In the present study we investigated IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3 production in cultured media from three human lung cancer cell lines (Calu-3, Calu-6, A549) and in human neoplastic and normal lung tissue samples obtained at surgery fr...

ea0035p525 | Endocrine tumours and neoplasia | ECE2014

The presence of B-RAF V600E and K601E mutations in our Ligurian population

Eleonora Monti , Lorenzo Mortara , Simonetta Zupo , Gianluca Ansaldo , Mauro Truni , Francesco Minuto , Massimo Giusti

Introduction: Differentiated thyroid carcinoma (DTC) is the most common endocrine neoplasm and its rate it’s constantly increasing. Papillary thyroid carcinoma (PTC) represents 87% of all DTC and its incidence is raising at 89%. The thyroid carcinoma preoperative diagnosis consists in fine-needle ago aspiration (FNAB). However in the diagnostic cytology there actually is a ‘grey zone’, the ‘follicular lesion of indeterminate significant or suspicious for fo...

ea0035p1088 | Thyroid Cancer | ECE2014

Estimated 10-year risk of bone fracture in women with diffentiated thyroid cancer on TSH-suppressive levo-thyroxine therapy

Vera Lara , Gay Stefano , Campomenosi Claudia , Mortara Lorenzo , Pera Giorgia , Monti Eleonora , Minuto Francesco , Giusti Massimo

After thyroidectomy (Tx) and RAI therapy, patients with diffentiated thyroid cancer are treated with levo-thyroxine to suppress TSH levels. Whether hyperthyroxinemia causes osteoporosis is debated. The aim of this study was to evaluate bone mineral density (BMD) and the fracture risk assessment tool (FRAX) in DTC women. FRAX calculates the 10-year probability of hip fracture (HF) and major osteoporotic fracture (MOF) in subjects aged >40. 46 women with DTC diagnosed and tr...

ea0032p630 | Growth hormome IGF axis – basic | ECE2013

First results from the PATRO adults study of omnitrope for the treatment of adult patients with GH deficiency

Stalla Gunter , Leal-Cerro Alfonso , Simsek Suat , Minuto Francesco , Zabransky Markus , Beck-Peccoz Paolo

Introduction: More data are needed to confirm the long-term safety of recombinant human GH (rhGH) in adult patients with severe GH deficiency (GHD), particularly with regard to diabetogenic potential. PATRO Adults is an ongoing observational, multicentre, open, longitudinal study of Omnitrope, being conducted in hospitals and specialised endocrinology clinics across Europe. Here, we present safety data from an interim analysis.Methods: Eligible patients ...

ea0022p423 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Reversible heart failure after sorafenib administration in advanced metastatic differentiated thyroid carcinoma (DTC)

Giusti Massimo , Derchi Maria , Mortara Lorenzo , Canepa Mario , Cecoli Francesca , Minuto Francesco , Spallarossa Paolo

Sorafenib (S) is a reasonably well-tolerated therapy in DTC. A large number of side-effects have been reported. We report our data on the effectiveness and tolerability of S in 6 patients with advanced metastatic epithelial (2 follicular, 1 papillary, 1 insular) and medullary DTCs (52–79 years). In all patients, heart function was evaluated before and during S administration (400 mg/day) together with the objective response rate and changes in serum markers. Underlying he...

ea0020p70 | Thyroid | ECE2009

Recombinant-human TSH (rhTSH) testing in patients with history of thyroid microcarcinomas

Capitanio Selene , Cecoli Francesca , Mortara Lorenzo , Fiz Francesco , Caorsi Valeria , Minuto Francesco , Giusti Massimo

Papillary thyroid microcarcinoma (mPTC) is being diagnosed increasingly frequently. Multifocality and nodal involvement are sometimes reported on diagnosis. Management ranges from observation to total thyroidectomy (Tx) followed by radioiodine (RAI) ablation. The role of rhTSH testing in mPTC has not been fully investigated. Torlontano et al. (2006) recently observed that rhTSH-stimulated Tg levels mainly depend on normal tissue remnant. Aim of this study was to further...

ea0020p252 | Bone/Calcium | ECE2009

Metabolic and cardiovascular risk in primary hyperparathyroidism

Dolcino Mara , Massaro Francesca , Vera Lara , Oddo Silvia , Rodriguez Guido , Ferone Diego , Minuto Francesco , Giusti Massimo

Background: Primary hyperparathyroidism (PHP) is associated with increased rates of cardiovascular (CV) risk. Moreover, it is not fully clear whether surgery can attenuate CV risk. The intima-media thickness (IMT) of carotid vessels is considered a marker of atherosclerosis and CV events.Aim: Of the study was to evaluate IMT and some metabolic parameters in PHP patients.Subjects: Of 56 subjects were studied. Patients were divided i...

ea0020p360 | Diabetes and Cardiovascular | ECE2009

Effects of estrogen therapy on cardiovascular risk factor in transsexuals

Bochetti Mara , Casalino Laura , Agosti Sergio , Teti Claudia , Minuto Francesco M , Ferone Diego

Estrogens play a protective role on the peripheral vascular endothelium in both females and males, however, no studies have reported on the effects of estrogens on male coronary arterial reactivity. We investigated the effects of estrogen therapy on coronary and endothelial function in a group of male to female transsexuals (M-to-F).Eight M-to-F transsexuals (group A), receiving oral estrogen therapy for 72 months were studied in comparison with 23 age-m...

ea0014p215 | (1) | ECE2007

Absence of TSH-induced increase in leptin levels in patients with history of differentiated thyroid carcinoma undergoing rhTSH testing

Cecoli Francesca , Andraghetti Gabriella , Ghiara Carla , Briatore Lucia , Cavallero Domenico , Mussap Michele , Minuto Francesco , Giusti Massimo

Some extra-thyroid effects of TSH have been described in vitro and in vivo. TSH has recently been suggested to induce IL-6 secretion from adipocytes. Leptin is the main secretory protein from adipose tissue. Our aim was to evaluate the acute effect of rhTSH-induced TSH surge on serum leptin levels in differentiated thyroid carcinoma (DTC) patients. Ten patients (2 m, 8 f; age range 31–66 years) with stage 1-3 DTC were evaluated during scheduled standard rhTS...