Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep1066 | Hot topics (including COVID-19) | ECE2020

Effect of long term rhgh treatment on bone mineral density in patients with childhood onset growth hormone deficiency

Dassie Francesca , Spinazze Alice , Russo Lucia , Parolin Matteo , Mioni Roberto , Maffei Pietro , Zaccaria Marco , Vettor Roberto , De Carlo Eugenio

Background: RhGH treatment in adults with childhood onset growth hormone deficiency (COGHD) affect bone metabolism over time according to gender and age. A long-term study of bone mass density (BMD) in young-middle age hypopituitary patients with COGHD may better highlight possible benefits of therapy and improve clinical follow up.Methods: We enrolled 40 adults (age range during follow-up: 16.8–36 years, F: 38%) with COGHD with at least 20 years o...

ea0063p256 | Pituitary and Neuroendocrinology 1 | ECE2019

Hyperglycemia and pasireotide lar in acromegaly: a study with continuous glucose monitoring

Russo Lucia , Mazzocut Sara , Dassie Francesca , Parolin Matteo , Martini Chiara , Carlo Eugenio De , Fallo Francesco , Mioni Roberto , Vettor Roberto , Maran Alberto , Maffei Pietro

Background: Pasireotide LAR is a multireceptor targeted somatostatin analogue that has been shown to obtain a better biochemical control of acromegaly. However, pasireotide LAR could induce hyperglycemia in acromegalic patients with higher baseline glucose values. The devices that can track interstitial glucose levels such as continuous glucose monitoring (CGM) could be a useful for studying the impact of SSA on patientsÂ’ glucose status.Aim: We aime...

ea0063p1101 | Pituitary and Neuroendocrinology 3 | ECE2019

Pegvisomant: daily versus non daily administration a single centre real life study

Dassie Francesca , Rosson Marco , Parolin Matteo , Russo Lucia , Mazzocut Sara , Martini Chiara , De Carlo Eugenio , Mioni Roberto , Fallo Francesco , Vettor Roberto , Maffei Pietro

Background: Pegvisomant (PEG) is a second line medical treatment for active acromegalic patients. PEG efficacy is between 61.5 and 92% and even if it is administered daily its long half-life suggests a possible use with a non-daily regime.Aim: We aim to compare acromegalic patients on daily PEG administration (DP) with patients on non-daily PEG administration (NDP).Methods: We studied 43 acromegalic patients under PEG treatment bet...

ea0041ep903 | Pituitary - Clinical | ECE2016

Acromegalic cardiomyopathy: echocardiographic and CMR analysis

Casara Alvise , Dassie Francesca , Battocchio Marialberta , Parolin Matteo , Martini Chiara , De Carlo Eugenio , Mioni Roberto , Famoso Giulia , Tona Francesco , Fallo Francesco , Vettor Roberto , Corbetti Francesco , Maffei Pietro

Introduction: Acromegalic cardiomyopathy is characterized by myocardial hypertrophy and interstitial myocardial fibrosis at biopsy. We studied left ventricular hypertrophy -LVH- through echocardiography (-ECHO- 2-D standard echocardiography and Doppler analysis) and cardiac magnetic resonance (CMR) analysis. Myocardial fibrosis was studied with late enhancement technique (LE) and extracellular volume technique (ECV) at CMR.Methods: 25 patients -pts- (13 ...

ea0022p483 | Female reproduction | ECE2010

AMH secretion seems not to be influenced by acute GnRH-analogue administration in PCOS patients

Mioni Roberto , Ritunnano Rosa , Cosma Chiara , Zuliani Laura , Glinski Letizia , Azzolini Sara , Bleve Luigi , Granzotto Marnie , Maffei Piero , Faggian Diego , Sicolo Nicola , Vettor Roberto

Background: Hyperandrogenism and disrupted folliculogenesis are prominent features of polycystic ovary syndrome (PCOS) and are causatively linked to ovarian dysfunction. In PCOS, increased anti-Müllerian hormone (AMH) serum levels have been observed and related to the severity of the phenotype. However, the regulation of AMH in PCOS remains poorly understood. Therefore, we compared AMH secretory pattern after acute exposure to a GnRH-analogue in women affected by PCOS or ...

ea0014p567 | (1) | ECE2007

Medial cerebral artery occlusion 25 years after cranial radiation therapy in acromegaly

Maffei Pietro , Martini Chiara , Barban Martina , Carli Marta , Manara Renzo , Scanarini Massimo , Mazzarotto Renzo , Meneghetti Giorgio , Menegazzo Carla , Mioni Roberto , De Carlo Eugenio , Vettor Roberto , Sicolo Nicola

Introduction: Epidemiological studies indicate that patients with acromegaly have increased mortality rates for cardiovascular and cerebrovascular disease (CVD). Potentials risk factors for increased CVD include hypopituitarism and cranial radiation therapy (CRT).Case Report: A 43-year-old acromegalic woman was admitted because of worsening headache, left lower facial numbness and left arm weakness. Two weeks later she developed a central palsy of the le...