Endocrine Abstracts

Introduction: Primary hyperparathyroidism is usually caused by parathyroid adenoma or hyperplasia. Parathyroid carcinoma is a rare cause of hyperparathyroidism with a frequency ranged from 0.3 to 2.1%. Features that increase the likelihood of parathyroid carcinoma in patients with primary hyperparathyroidism are larger tumor size, symptomatic disease, marked hypercalcemia, and very high serum parathyroid hormone (PTH) concentrations. Preoperative localization studies do not re...

Introduction: We diagnosed multiple endocrine neoplasia type 1 (MEN1) based upon the occurrence of two primary MEN1 tumor types in patient without family history of MEN1. Hyperparathyroidism was diagnosed in patient five years after gastrinoma surgery. With hormone tests and morphologic investigation we excluded pituitary adenoma.Case report: Forty-nine year old patient was admitted with abdominal pain and vomiting. Laboratory testing revealed elevated v...

An 82-year old female with known osteoporosis was reassessed for bone mineral density (BMD) measurement. Her baseline BMD and lumbar spine T-score (L1-L4) measured in 2004 was 0.699 g/cm2, –3.5 SD, total left hip T-score was 0.618 g/cm2, –2.7 S.D. She was treated with alendronate 70 mg, cholecalciferol 7000 IE per week and calcium supplements for some years. On follow-up in 2013 DXA of lumbar spine and hip, BMD of lumbar spine L1-...

Introduction: An 80-year old female with known osteoporosis was reassessed for BMD measurement. Her baseline BMD and T-score of lumbar spine (L1–L4) measured in 2004 were 0.699 g/cm2, −3.5 S.D., T-score of total left hip was 0.618 g/cm2, −2.7 S.D.. She was treated with alendronate 70 mg, cholecalciferol 7000 IE per week and calcium supplements.Case report: At follow-up...

Introduction: Coronary calcification (quantified as Agatston’s calcium score (CS) and measured with a CT-based method) has been shown to predict coronary atherosclerotic burden and mortality in type 2 diabetics (T2D). Compared to a single measurement, the progression of CS in time better reflects the effects of cardiovascular risk factors that have not yet been fully elucidated.Methods: We measured calcium score (CS) (Agatston’s method, 64-slic...

Introduction: Maternally-inherited diabetes with deafness (MIDD) is a rare form of monogenetic diabetes caused by a point mutation in mitochondrial DNA at a position 3243A>G. The syndrome is characterised by diabetes and sensoneural hearing impairment. Additional clinical features include short stature, cardiomyopathy, myopathy, renal disease, macular dystrophy, and gastrointestinal disease. The majority of patients usually require insulin therapy within 2 years and metfor...

Objective: To analyse the semen quality in patients with newly diagnosed non-Hodgkin lymphoma before starting the treatment.Materials and methods: We evaluated semen quality in 29 patients with non-Hodgkin lymphoma who underwent sperm banking in our clinic over a 9-year period. Semen samples were collected by masturbation after 2–7 days of sexual abstinence. Age at banking, semen volume, sperm concentration, and total and progressive sperm motility ...

Purpose: Treatment with tyrosine kinase inhibitors (TKI) has been associated with alterations in circulating thyroid hormone levels, possibly related to perturbations in peripheral thyroid hormone metabolism. In this study, we evaluated the effect of the multi-kinase inhibitor vandetanib on the expression of the three deiodinase selenoenzymes.Materials and Methods: Cell models that endogenously express either D1 (HepG2 and HEK-293), D2 (HeLa and KMH-2) o...

The iodothyronine deiodinases constitute a family of three selenoenzymes regulating the intracellular metabolism of Thyroid Hormones (THs, T4 and T3) and impacting on several physiological processes, including energy metabolism, development and cell differentiation. The type 1, 2 and 3 deiodinases (D1, D2, and D3), are sensitive, rate-limiting components within the TH axis, and rapidly control TH action in physiological conditions or disease. Notably, several human pathologies...

Introduction: Falsely elevated serum chromogranin A (CgA) is associated with the use of proton pump inhibitors, the presence of renal impairment and systemic inflammation. We aimed to investigate which laboratory parameters are independently associated with increased CgA and to develop a nomogram, in order to improve the diagnostic accuracy of CgA in detecting patients with neuroendocrine tumors (NET).Methods: Our retrospective study included 155 subject...