Endocrine Abstracts

Introduction: Primary hyperparathyroidism is usually caused by parathyroid adenoma or hyperplasia. Parathyroid carcinoma is a rare cause of hyperparathyroidism with a frequency ranged from 0.3 to 2.1%. Features that increase the likelihood of parathyroid carcinoma in patients with primary hyperparathyroidism are larger tumor size, symptomatic disease, marked hypercalcemia, and very high serum parathyroid hormone (PTH) concentrations. Preoperative localization studies do not re...

Introduction: We diagnosed multiple endocrine neoplasia type 1 (MEN1) based upon the occurrence of two primary MEN1 tumor types in patient without family history of MEN1. Hyperparathyroidism was diagnosed in patient five years after gastrinoma surgery. With hormone tests and morphologic investigation we excluded pituitary adenoma.Case report: Forty-nine year old patient was admitted with abdominal pain and vomiting. Laboratory testing revealed elevated v...

An 82-year old female with known osteoporosis was reassessed for bone mineral density (BMD) measurement. Her baseline BMD and lumbar spine T-score (L1-L4) measured in 2004 was 0.699 g/cm2, –3.5 SD, total left hip T-score was 0.618 g/cm2, –2.7 S.D. She was treated with alendronate 70 mg, cholecalciferol 7000 IE per week and calcium supplements for some years. On follow-up in 2013 DXA of lumbar spine and hip, BMD of lumbar spine L1-...

Introduction: An 80-year old female with known osteoporosis was reassessed for BMD measurement. Her baseline BMD and T-score of lumbar spine (L1–L4) measured in 2004 were 0.699 g/cm2, −3.5 S.D., T-score of total left hip was 0.618 g/cm2, −2.7 S.D.. She was treated with alendronate 70 mg, cholecalciferol 7000 IE per week and calcium supplements.Case report: At follow-up...

Introduction: Coronary calcification (quantified as Agatston’s calcium score (CS) and measured with a CT-based method) has been shown to predict coronary atherosclerotic burden and mortality in type 2 diabetics (T2D). Compared to a single measurement, the progression of CS in time better reflects the effects of cardiovascular risk factors that have not yet been fully elucidated.Methods: We measured calcium score (CS) (Agatston’s method, 64-slic...

Introduction: Maternally-inherited diabetes with deafness (MIDD) is a rare form of monogenetic diabetes caused by a point mutation in mitochondrial DNA at a position 3243A>G. The syndrome is characterised by diabetes and sensoneural hearing impairment. Additional clinical features include short stature, cardiomyopathy, myopathy, renal disease, macular dystrophy, and gastrointestinal disease. The majority of patients usually require insulin therapy within 2 years and metfor...

Objective: To analyse the semen quality in patients with newly diagnosed non-Hodgkin lymphoma before starting the treatment.Materials and methods: We evaluated semen quality in 29 patients with non-Hodgkin lymphoma who underwent sperm banking in our clinic over a 9-year period. Semen samples were collected by masturbation after 2–7 days of sexual abstinence. Age at banking, semen volume, sperm concentration, and total and progressive sperm motility ...

Introduction: Falsely elevated serum chromogranin A (CgA) is associated with the use of proton pump inhibitors, the presence of renal impairment and systemic inflammation. We aimed to investigate which laboratory parameters are independently associated with increased CgA and to develop a nomogram, in order to improve the diagnostic accuracy of CgA in detecting patients with neuroendocrine tumors (NET).Methods: Our retrospective study included 155 subject...

Aims: Diabetic ketosis (DK) and diabetic ketoacidosis (DKA) are known complications of type 1 diabetes mellitus (T1DM). However, DK and DKA have been described in T2DM. Referred to as ketosis-prone T2DM, this subtype of T2DM has been described in Hispanics and Afro-Americans of sub-Saharan Africa, but the incidence and pathogenesis remains unknown. We aimed to analyze characteristics of patients with diabetic ketosis (DK) and diabetic ketoacidosis (DKA) in Ca...

Introduction: Little is known about diabetic ketoacidosis (DKA) in type 2 diabetes mellitus (T2DM). Moreover, the clinical impact of diabetic ketosis (DK) in T2DM is elusive. The aim of this study was to analyze characteristics and mortality of patients with DKA and DK and to identify possible prognostic factors.Methods: This was a population-based, cross-sectional study that included all patients with T2DM presenting to emergency department with DKA, ov...